What is the NOAEL for Valproic acid?
Valproic acid has 44 NOAEL studies in the database. The lowest reported value is developmental listing type. Source: California Proposition 65.
NOAEL Data
Prop 65
REACH Registered
Cosmetic Ingredient
Valproic acid
Also known as: VPA, Pentanoic acid, 2-propyl-, 2,2-Di-n-propylacetic acid, Depakine-chrono, Sigma V 0033000 (+15 more)
CAS 99-66-1
Valproic acid (CAS 99-66-1) is a chemical substance; key hazard signal: developmental. Key regulatory status: California Proposition 65, REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Valproic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H336, H362).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
44
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Valproic acid
CAS Number
99-66-1
DTXSID
DTXSID6023733
Molecular Formula
C8H16O2
InChI Key
NIJJYAXOARWZEE-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
VPAPentanoic acid, 2-propyl-2,2-Di-n-propylacetic acidDepakine-chronoSigma V 00330002-Propan-1-ylpentanoic acid44089Abbott 44090BRN 1750447Di-n-propylacetic acidEINECS 202-777-3Acide valproique
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental | No | Yes | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 44 of 44 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQEdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 0.4366 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 4.6 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| 614OI1Z5WI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 614OI1Z5WI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 614OI1Z5WI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 614OI1Z5WI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.214 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0.37 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| =159 | mg/kg bw/day | LEL | oral | Mouse | ECHA |
| =161 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| =163 | mg/kg bw/day | LEL | oral | Mouse | ECHA |
| =172 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| ~300 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =1.56 | mmol/kg | LOEL | oral | Rat | ToxValDB ECOTOX |
| =3.13 | mmol/kg | LOEL | oral | Rat | ToxValDB ECOTOX |
| =600 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB ECOTOX |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| =90 | mg/kg bw/day | NOAEL | oral | Dog | ECHA |
| ~100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~150 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =152 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =203 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =341 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =416 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =600 | mg/day | NOAEL | - | Mammalian cell line | EFSA |
| =600 | mg/kg bw/day | NOAEL | - | Unspecified | EFSA |
| =600 | mg/day | NOAEL | - | Mammalian cell line | EFSA |
| =600 | mg/kg bw/day | NOAEL | - | Unspecified | EFSA |
| =0.04 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =34.5 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =38 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =69 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =138 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =152 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =172.5 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =276 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =9.38 | mmol/kg | NOEL | oral | Rat | ToxValDB ECOTOX |
| =400 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
| =600 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB ECOTOX |
Showing 44 of 44 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-propylvaleric acid | 202-777-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
VALPROIC ACID
ChEMBL Phase
4
Adverse Events
4360
Bioactivity
17
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Valproic acid?
Valproic acid appears on 5 regulatory/inventory lists including pharmaceutical, OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), and 2 more. Source: EPA CPDat.
Is Valproic acid on the California Proposition 65 list?
Yes, Valproic acid is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.
Is Valproic acid used in cosmetics?
Yes, Valproic acid is also indexed as a cosmetic ingredient under the name Valproic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Valproic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Valproic acid have different safety status in cosmetics vs industrial chemicals?
Valproic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H318, H319, H335, H360, H336, H362).
Is Valproic acid used outside industrial chemicals?
Valproic acid also appears in cosmetics, pharmaceutical, cannabis databases.