Warning GHS02GHS07 NOAEL Data IARC Group 2B REACH Registered Cosmetic Ingredient

Butyl methacrylate

Also known as: 2-Propenoic acid, 2-methyl-, butyl ester, BRN 0773960, Butylmethacrylate, EINECS 202-615-1, 2-Methylacrylic acid, butyl ester (+8 more)

CAS 97-88-1

Butyl methacrylate (CAS 97-88-1) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335; H315; H319; H317. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Butyl Methacrylate →

SOURCE noael studies public
NOAEL studies
41
SOURCE chemical inventory jurisdictions
Regulatory lists
23
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
Butyl methacrylate
CAS Number
97-88-1
DTXSID
DTXSID4024696
Molecular Formula
C8H14O2
InChI Key
SOGAXMICEFXMKE-UHFFFAOYSA-N
Monoisotopic Mass
142.09938
Synonyms
2-Propenoic acid, 2-methyl-, butyl esterBRN 0773960ButylmethacrylateEINECS 202-615-12-Methylacrylic acid, butyl ester2-Methyl-butylacrylate2-Methyl-butylacrylaat2-Methyl-butylacrylatButil metacrilatoButylester kyseliny methakryloveButylmethacrylaatMethacrylsaeurebutylester

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 2BPossibly carcinogenic2023133

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1H226; H335; H315; H319; H317GHS02; GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordWARNING
GHS Hazard StatementsFlammable liquid and vapour Causes skin and eye irritation May cause an allergic skin reaction May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term EffectsLachrymation. The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by inhalation.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records
Film formerDeodorizerViscosity modifierBinderFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 23 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - nailsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Cons electronics mech appliances and machinery; detected; EuropeDanish EPADanish EPA
Cons electronics mech appliances and machinery; detected; EuropeDanish EPADanish EPA
Cons electronics mech appliances and machinery; detected; EuropeDanish EPADanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - nailsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - nails - nail polishDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 41 of 41 studies
ValueUnitEndpointRouteSpeciesSource
=409mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
=415.9mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
R5QX287XXUUNIIFDA UNII substance identifier--openFDA substances
R5QX287XXUUNIIFDA UNII substance identifier--openFDA substances
R5QX287XXUUNIIFDA UNII substance identifier--openFDA substances
R5QX287XXUUNIIFDA UNII substance identifier--openFDA substances
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
28.5382mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=16000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=22600mg/kg bwLD50oralRatNTP_ICE_acute_oral
>=1163.18mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=6000mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=19700mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=29000mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=5536.73mg/m3LOAECinhalationRatToxValDB_ECHA_IUCLID
=581.59mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=1744.77mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=1802.93mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=10997.9mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=30mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
=120mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=300mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
=360mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=3501.17mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
-%Positive reactionDermalHumanNTP_ICE_skin_irritation
10.65%ViabilityDermal-NTP_ICE_skin_irritation
11.25%ViabilityDermal-NTP_ICE_skin_irritation
22.5%ViabilityDermal-NTP_ICE_skin_irritation
25.6%ViabilityDermal-NTP_ICE_skin_irritation
28.7%ViabilityDermal-NTP_ICE_skin_irritation
39.2%ViabilityDermal-NTP_ICE_skin_irritation
39.8%ViabilityDermal-NTP_ICE_skin_irritation
59.5%ViabilityDermal-NTP_ICE_skin_irritation
66.3%ViabilityDermal-NTP_ICE_skin_irritation
92.64%ViabilityDermal-NTP_ICE_skin_irritation
98.11%ViabilityDermal-NTP_ICE_skin_irritation

Showing 41 of 41 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredButyl methacrylate202-615-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183073
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Butyl methacrylate?

Butyl methacrylate (CAS 97-88-1) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H226; H335; H315; H319; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Butyl methacrylate?

Butyl methacrylate has 41 NOAEL studies in the database. The lowest reported value is 409 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Butyl methacrylate?

Butyl methacrylate appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), detected; Europe; Personal care - nails - nail polish, and 6 more. Source: EPA CPDat.

Is Butyl methacrylate a carcinogen according to IARC?

Butyl methacrylate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2023). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Butyl methacrylate used in cosmetics?

Yes, Butyl methacrylate is also indexed as a cosmetic ingredient under the name Butyl Methacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Butyl methacrylate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Butyl methacrylate used outside industrial chemicals?

Butyl methacrylate also appears in cosmetics, pharmaceutical, cannabis databases.