What is the NOAEL for Propanoic acid, 2-methyl-, butyl ester?
Propanoic acid, 2-methyl-, butyl ester has 11 NOAEL studies in the database. The lowest reported value is 5 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
Propanoic acid, 2-methyl-, butyl ester
Also known as: Butyl isobutanoate, Butyl 2-methylpropanoate, EINECS 202-614-6, FEMA No. 2188, UNII-PW9UJ5C0F3
CAS 97-87-0
Propanoic acid, 2-methyl-, butyl ester (CAS 97-87-0) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Propanoic acid, 2-methyl-, butyl ester
CAS Number
97-87-0
DTXSID
DTXSID9073888
Molecular Formula
C8H16O2
InChI Key
JSLCOZYBKYHZNL-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
Butyl isobutanoateButyl 2-methylpropanoateEINECS 202-614-6FEMA No. 2188UNII-PW9UJ5C0F3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| PW9UJ5C0F3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PW9UJ5C0F3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PW9UJ5C0F3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PW9UJ5C0F3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Propanoic acid, 2-methyl-, butyl ester?
Propanoic acid, 2-methyl-, butyl ester appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Propanoic acid, 2-methyl-, butyl ester used in cosmetics?
Yes, Propanoic acid, 2-methyl-, butyl ester is also indexed as a cosmetic ingredient under the name Butyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propanoic acid, 2-methyl-, butyl ester come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Propanoic acid, 2-methyl-, butyl ester used outside industrial chemicals?
Propanoic acid, 2-methyl-, butyl ester also appears in cosmetics, food safety databases.