What is the NOAEL for Ethyl isobutyrate?
Ethyl isobutyrate has 8 NOAEL studies in the database. The lowest reported value is 9A9661LN4H UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl isobutyrate
Also known as: BRN 0773846, EINECS 202-595-4, FEMA No. 2428, Propionic acid, 2-methyl-, ethyl ester, UNII-9A9661LN4H (+1 more)
CAS 97-62-1
Ethyl isobutyrate (CAS 97-62-1) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ethyl isobutyrate is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Ethyl isobutyrate
CAS Number
97-62-1
DTXSID
DTXSID7047728
Molecular Formula
C6H12O2
InChI Key
WDAXFOBOLVPGLV-UHFFFAOYSA-N
Monoisotopic Mass
116.08373
Synonyms
BRN 0773846EINECS 202-595-4FEMA No. 2428Propionic acid, 2-methyl-, ethyl esterUNII-9A9661LN4Hisobutyric acid ethyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
23 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9A9661LN4H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A9661LN4H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A9661LN4H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9A9661LN4H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 29.2 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl isobutyrate | 202-595-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL295870
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl isobutyrate?
Ethyl isobutyrate appears on 6 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 3 more. Source: EPA CPDat.
Is Ethyl isobutyrate used in cosmetics?
Yes, Ethyl isobutyrate is also indexed as a cosmetic ingredient under the name Ethyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethyl isobutyrate have different safety status in cosmetics vs industrial chemicals?
Ethyl isobutyrate is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
Is Ethyl isobutyrate used outside industrial chemicals?
Ethyl isobutyrate also appears in cosmetics, pharmaceutical, cannabis databases.