What is the NOAEL for Isoeugenol?
Isoeugenol has 100 NOAEL studies in the database. The lowest reported value is 0.5 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
IARC Group 2B
Cosmetic Ingredient
Isoeugenol
Also known as: 3-06-00-04993, BRN 1909602, EINECS 202-590-7, FEMA No. 2468, 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene (+8 more)
CAS 97-54-1
Isoeugenol (CAS 97-54-1) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: 34 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
34
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Isoeugenol
CAS Number
97-54-1
DTXSID
DTXSID7022413
Molecular Formula
C10H12O2
InChI Key
BJIOGJUNALELMI-UHFFFAOYSA-N
Monoisotopic Mass
164.08373
Synonyms
3-06-00-04993BRN 1909602EINECS 202-590-7FEMA No. 24681-Hydroxy-2-methoxy-4-propen-1-ylbenzene4-Hydroxy-3-methoxy-1-propen-1-ylbenzene3-Methoxy-4-hydroxy-1-propen-1-ylbenzeneNCI-C60979UNII-5M0MWY797U1-Hydroxy-2-methoxy-4-propenylbenzene3-Methoxy-4-hydroxypropenylbenzene4-Hydroxy-3-methoxypropenylbenzene
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2023 | 134 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrientProcessing aids not otherwise specifiedDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
34 records
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Cleaning products and household care - air freshener; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; nondetect; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - general household cleaning - surface cleaner; Cleaning products and household care - laundry and fabric treatment; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 56.0165711806361 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 48.2923742954896 | uM | ACC | - | - | NTP_ICE_endocrine |
| =75 | µg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =75 | µg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 15 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 17 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 44.76 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 115.29 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 48.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 112.5 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 71.78 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 3.244 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.8889 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 55.8 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 89.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 99.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 10.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 12.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 21.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 34 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 50 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 60.45 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.86 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 3 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.5 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.73 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.29 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 12.1 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 13.42 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.3 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.62 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 15.2 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 15.27 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 16.064 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 17.05 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 17.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 18.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 19.34 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 20.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 22.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 23.3 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 29.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 35.58 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 36.21 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| <120.56 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 562.39 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.5 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
>10 ppm leave-on / >100 ppm rinse-off
Category
fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isoeugenol?
Isoeugenol appears on 23 regulatory/inventory lists including Europe, Cleaning products and household care - air freshener; Europe, active_ingredient; Australia, and 20 more. Source: EPA CPDat.
Is Isoeugenol a carcinogen according to IARC?
Isoeugenol is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2023). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Isoeugenol used in cosmetics?
Yes, Isoeugenol is also indexed as a cosmetic ingredient under the name Isoeugenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isoeugenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Isoeugenol used outside industrial chemicals?
Isoeugenol also appears in cosmetics, food safety, cannabis databases.