Warning GHS07GHS09 NOAEL Data Prop 65 Cosmetic Ingredient

Dichlorophen

Also known as: 2,2'-Methylene-bis (4-chlorophenol), Anthiphen, Antifen, Antiphen, Bis(chlorohydroxyphenyl)methane (+15 more)

CAS 97-23-4

Dichlorophen (CAS 97-23-4) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319; H400; H410. Key regulatory status: California Proposition 65, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, CA Prop 65, EPA TRI.

View cosmetic safety profile for Dichlorophene →

SOURCE noael studies public
NOAEL studies
75
SOURCE chemical inventory jurisdictions
Regulatory lists
13
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Dichlorophen
CAS Number
97-23-4
DTXSID
DTXSID6021824
Molecular Formula
C13H10Cl2O2
InChI Key
MDNWOSOZYLHTCG-UHFFFAOYSA-N
Monoisotopic Mass
268.005785
Synonyms
2,2'-Methylene-bis (4-chlorophenol)AnthiphenAntifenAntiphenBis(chlorohydroxyphenyl)methaneBis(5-chloro-2-hydroxyphenyl)methaneBis(2-hydroxy-5-chlorophenyl)methaneBRN 1884514Caswell No. 563CordocelDDM (VAN)Dicestal

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-developmentalNoYes-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1H302; H319; H400; H410GHS07; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
BiocideDeodorizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 13 records
ListKeywordSource
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
inert_ingredient; non_food_use; PesticidesEPACPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 75 studies
ValueUnitEndpointRouteSpeciesSource
1mg/kg/day-dermalrabbitUnifiedCodex:CIR:beta.noael_studies
25mg/kg/day-dermalrabbitUnifiedCodex:CIR:beta.noael_studies
15.48201604uMAC50--NTP_ICE_endocrine
17.199492691799uMAC50--NTP_ICE_endocrine
14.8521862953658uMACC--NTP_ICE_endocrine
16.0241547366554uMACC--NTP_ICE_endocrine
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
13.2uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
37.5%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
110%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
5%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
20%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
T1J0JOU64OUNIIFDA UNII substance identifier--openFDA substances
T1J0JOU64OUNIIFDA UNII substance identifier--openFDA substances
T1J0JOU64OUNIIFDA UNII substance identifier--openFDA substances
T1J0JOU64OUNIIFDA UNII substance identifier--openFDA substances
0.0045fractionFu-HumanNTP_ICE_adme_parameters
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.6667%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.9091%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
3488ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
5625ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
13950ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
42187.5ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
76730ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
=1506mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=1683mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
-unitlessModel Score--NTP_ICE_endocrine
0.0058unitlessModel Score--NTP_ICE_endocrine
0.0643unitlessModel Score--NTP_ICE_endocrine
0.337unitlessModel Score--NTP_ICE_endocrine
=1mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=1mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=1mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=1mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=25mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=25mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=25mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=25mg/kg/dayNOAELdermalrabbitCIR_vision_codex
=30mg/kg/dayNOAEL-ratCIR_vision_codex
=30mg/kg/dayNOAEL-ratCIR_vision_codex
=30mg/kg/dayNOAEL-ratCIR_vision_codex
=30mg/kg/dayNOAEL-ratCIR_vision_codex
=75mg/kg/dayNOAEL-ratCIR_vision_codex
=75mg/kg/dayNOAEL-ratCIR_vision_codex
=75mg/kg/dayNOAEL-ratCIR_vision_codex
=75mg/kg/dayNOAEL-ratCIR_vision_codex
<100mg/kg/dayNOAELoralratCIR_vision_codex

Showing 50 of 75 studies

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Dichlorophene--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
0.5%
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DICHLOROPHEN
ChEMBL Phase
2
Adverse Events
0
Bioactivity
9
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Dichlorophen?

Dichlorophen (CAS 97-23-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H302; H319; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Dichlorophen?

Dichlorophen has 75 NOAEL studies in the database. The lowest reported value is 1 mg/kg/day via dermal in rabbit. Source: UnifiedCodex:CIR:beta.noael_studies.

What regulatory lists include Dichlorophen?

Dichlorophen appears on 11 regulatory/inventory lists including Indirect additives food contact (10/2018), active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 8 more. Source: EPA CPDat.

Is Dichlorophen on the California Proposition 65 list?

Yes, Dichlorophen is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

Is Dichlorophen used in cosmetics?

Yes, Dichlorophen is also indexed as a cosmetic ingredient under the name Dichlorophene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dichlorophen come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Dichlorophen have different safety status in cosmetics vs industrial chemicals?

Dichlorophen is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H302, H319, H400, H410).

Is Dichlorophen used outside industrial chemicals?

Dichlorophen also appears in cosmetics, pharmaceutical databases.