What is the NOAEL for 1-Thioglycerol?
1-Thioglycerol has 41 NOAEL studies in the database. The lowest reported value is 0.00002798 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Thioglycerol
Also known as: 3-01-00-02339, BRN 1732046, EINECS 202-495-0, Glycerol, 1-thio-, 3-Mercapto-1,2-propanediole (+5 more)
CAS 96-27-5
1-Thioglycerol (CAS 96-27-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
1-Thioglycerol is classified GHS Danger (H302, H311, H315, H317, H319, H331, H335) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
41
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
1-Thioglycerol
CAS Number
96-27-5
DTXSID
DTXSID5046512
Molecular Formula
C3H8O2S
InChI Key
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
Monoisotopic Mass
108.024501
Synonyms
3-01-00-02339BRN 1732046EINECS 202-495-0Glycerol, 1-thio-3-Mercapto-1,2-propanediolealpha-ThiolglycerolUNII-AAO1P0WSXJmonothioglycerinmonothioglycerolthioglycerine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
Reducing agentDepilatoryHair waving or straighteningPharmaceuticalHeat stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 41 of 41 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 88.21 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 813.6 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 2860.4 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.182 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.4 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.556 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.00002798 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.818 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 2 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.083 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.222 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.49 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| AAO1P0WSXJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AAO1P0WSXJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AAO1P0WSXJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AAO1P0WSXJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.5 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| range10 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 39.13 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 41.67 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 45.83 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 100 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1453 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 12410 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 31030 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| range631.7 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1354 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1490 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1552 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1586 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| range242 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1129 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1241 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1293 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1379 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 41 of 41 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-mercaptopropane-1,2-diol | 202-495-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
MONOTHIOGLYCEROL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 1-Thioglycerol?
1-Thioglycerol appears on 1 regulatory/inventory list including active_ingredient; animal_products; Europe; pharmaceutical; residue. Source: EPA CPDat.
Is 1-Thioglycerol used in cosmetics?
Yes, 1-Thioglycerol is also indexed as a cosmetic ingredient under the name Thioglycerin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Thioglycerol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Thioglycerol have different safety status in cosmetics vs industrial chemicals?
1-Thioglycerol is classified GHS Danger (H302, H311, H315, H317, H319, H331, H335) in the chemicals database but is restricted in EU cosmetics.
Is 1-Thioglycerol used outside industrial chemicals?
1-Thioglycerol also appears in cosmetics, pharmaceutical databases.