What is the NOAEL for 2-Methylbutanal?
2-Methylbutanal has 26 NOAEL studies in the database. The lowest reported value is 47H597M1YY UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methylbutanal
Also known as: Butanal, 2-methyl-, 2-Methylbutyraldehyde, 3-01-00-02813, Acetaldehyde, ethylmethyl-, BRN 1633540 (+12 more)
CAS 96-17-3
2-Methylbutanal (CAS 96-17-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Methylbutanal is classified GHS Danger (H225, H317, H319, H335, H411, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
26
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
2-Methylbutanal
CAS Number
96-17-3
DTXSID
DTXSID2021818
Molecular Formula
C5H10O
InChI Key
BYGQBDHUGHBGMD-UHFFFAOYSA-N
Monoisotopic Mass
86.073165
Synonyms
Butanal, 2-methyl-2-Methylbutyraldehyde3-01-00-02813Acetaldehyde, ethylmethyl-BRN 1633540EINECS 202-485-6FEMA No. 2691Methyl ethyl acetaldehydealpha-Methylbutanal2-Methyl-1-butanalalpha-Methylbutyraldehydealpha-Methylbutyric aldehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 47H597M1YY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47H597M1YY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47H597M1YY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 47H597M1YY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 49.2894 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =6400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6884 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 26 of 26 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methylbutyraldehyde | 202-485-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
2-METHYLBUTANAL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methylbutanal?
2-Methylbutanal appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Methylbutanal used in cosmetics?
Yes, 2-Methylbutanal is also indexed as a cosmetic ingredient under the name 2-Methylbutyraldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methylbutanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methylbutanal have different safety status in cosmetics vs industrial chemicals?
2-Methylbutanal is classified GHS Danger (H225, H317, H319, H335, H411, H401) in the chemicals database but is allowed in EU cosmetics.
Is 2-Methylbutanal used outside industrial chemicals?
2-Methylbutanal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.