Also known as: 4-13-00-00246, BRN 0774521, EINECS 202-442-1, 2-Methyl-para-phenylenediamine, para-Toluenediamine (+7 more)
CAS 95-70-5
2-Methyl-1,4-benzenediamine (CAS 95-70-5) is a chemical substance with GHS signal word Danger; key hazard signal: H332; H312; H301; H317; H411. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.
2-Methyl-1,4-benzenediamine is classified GHS Danger (H332, H312, H301, H317, H411) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Skin Sens. 1; Aquatic Chronic 2 | H332; H312; H301; H317; H411 | GHS06; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| - | Journal of Chemical Engineering & Process Technology | Published Articles |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| - | Regulatory Toxicology and Pharmacology | Published Articles |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.5 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/d | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.27 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 24JO8Z0RJU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 24JO8Z0RJU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 24JO8Z0RJU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 24JO8Z0RJU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =102 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 20 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.39 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.39 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.39 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.39 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.67 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.67 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.67 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.67 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.97 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methyl-p-phenylenediamine | 202-442-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1089/07 | 2 October 2007 | safe with restrictions | 2.0% | strong sensitiser; MoS adequate |
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Methyl-1,4-benzenediamine (CAS 95-70-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Skin Sens. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H332; H312; H301; H317; H411. Source: EU CLP Annex VI (ECHA).
2-Methyl-1,4-benzenediamine has 100 NOAEL studies in the database. The lowest reported value is 0.2 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
2-Methyl-1,4-benzenediamine appears on 1 regulatory/inventory list including Europe; Personal care - hair coloring. Source: EPA CPDat.
2-Methyl-1,4-benzenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 2-Methyl-1,4-benzenediamine is also indexed as a cosmetic ingredient under the name Toluene-2,5-Diamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Methyl-1,4-benzenediamine is classified GHS Danger (H332, H312, H301, H317, H411) in the chemicals database but is restricted in EU cosmetics at max 2.0%.
2-Methyl-1,4-benzenediamine also appears in cosmetics databases.