Warning GHS08GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

2-Aminophenol

Also known as: CI Oxidation Base 17, EINECS 202-431-1, 2-Hydroxyanaline, Nako Yellow ga, Questiomycin B (+1 more)

CAS 95-55-6

2-Aminophenol (CAS 95-55-6) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H302. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for O-Aminophenol →

SOURCE noael studies public
NOAEL studies
64
SOURCE chemical inventory jurisdictions
Regulatory lists
11
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
2-Aminophenol
CAS Number
95-55-6
DTXSID
DTXSID8024498
Molecular Formula
C6H7NO
InChI Key
CDAWCLOXVUBKRW-UHFFFAOYSA-N
Monoisotopic Mass
109.052764
Synonyms
CI Oxidation Base 17EINECS 202-431-12-HydroxyanalineNako Yellow gaQuestiomycin BUNII-23RH73DZ65

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *H341; H332; H302GHS08; GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by ingestion, through the skin and by inhalation of its aerosol.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 11 records
ListKeywordSource
Canada; pharmaceuticalDrugBankDrugBank
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
-Danish Environmental Protection AgencyDanish EPA
-Danish Environmental Protection AgencyDanish EPA
-Danish Environmental Protection AgencyDanish EPA
-Danish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 64 studies
ValueUnitEndpointRouteSpeciesSource
70mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
<0.1ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
0.32ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
1.1ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
8.02ug/mLCV70Dermal-NTP_ICE_skin_sensitization
6ug/mLCV75Dermal-NTP_ICE_skin_sensitization
96.2%Depletion CysDermal-NTP_ICE_skin_sensitization
18.1%Depletion LysDermal-NTP_ICE_skin_sensitization
57.15%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
1.1uMEC1.5Dermal-NTP_ICE_skin_sensitization
1.451uMEC1.5Dermal-NTP_ICE_skin_sensitization
0.4%EC3DermalMouseNTP_ICE_skin_sensitization
0.4%EC3DermalMouseNTP_ICE_skin_sensitization
0.4%EC3DermalMouseNTP_ICE_skin_sensitization
0.4%EC3DermalMouseNTP_ICE_skin_sensitization
0.5%EC3DermalMouseNTP_ICE_skin_sensitization
0.5%EC3DermalMouseNTP_ICE_skin_sensitization
0.5%EC3DermalMouseNTP_ICE_skin_sensitization
0.5%EC3DermalMouseNTP_ICE_skin_sensitization
5.367uMEC3Dermal-NTP_ICE_skin_sensitization
23RH73DZ65UNIIFDA UNII substance identifier--openFDA substances
23RH73DZ65UNIIFDA UNII substance identifier--openFDA substances
23RH73DZ65UNIIFDA UNII substance identifier--openFDA substances
23RH73DZ65UNIIFDA UNII substance identifier--openFDA substances
94.78uMIC50Dermal-NTP_ICE_skin_sensitization
138.2uMIC50Dermal-NTP_ICE_skin_sensitization
13.1ratioImaxDermal-NTP_ICE_skin_sensitization
13.53ratioImaxDermal-NTP_ICE_skin_sensitization
=951mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1300mg/kg bwLD50oralRatNTP_ICE_acute_oral
2mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.5%NOAELoralratSCCS_vision_codex
=0.5%NOAELoralratSCCS_vision_codex
=0.5%NOAELoralratSCCS_vision_codex
=0.5%NOAELoralratSCCS_vision_codex
=1.7mg/kg bw/dNOAELoralratSCCS_vision_codex
=1.7mg/kg bw/dNOAELoralratSCCS_vision_codex
=1.7mg/kg bw/dNOAELoralratSCCS_vision_codex
=1.7mg/kg bw/dNOAELoralratSCCS_vision_codex
=5mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=5mg/kg bw/dNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralratSCCS_vision_codex
=5mg/kg bw/dNOAELoralratSCCS_vision_codex
=15mg/kg bw/dNOAELoralratSCCS_vision_codex
=15mg/kg bw/dNOAELoralratSCCS_vision_codex
=15mg/kg bw/dNOAELoralratSCCS_vision_codex
=15mg/kg bw/dNOAELoralratSCCS_vision_codex
=70mg/kg bw/dNOAEL-humanSCCS_vision_codex
=70mg/kg bw/dNOAEL-humanSCCS_vision_codex

Showing 50 of 64 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-aminophenol202-431-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1398/1022 June 2010safe1.5%strong sensitiser; MoS adequate

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
2.0%
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL QUESTIOMYCIN B
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Aminophenol?

2-Aminophenol (CAS 95-55-6) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H341; H332; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Aminophenol?

2-Aminophenol has 64 NOAEL studies in the database. The lowest reported value is 0.004 mg/kg bw/day via oral in Human. Source: ToxValDB_RSL.

What regulatory lists include 2-Aminophenol?

2-Aminophenol appears on 4 regulatory/inventory lists including Canada; pharmaceutical, detected; Europe; Personal care - hair coloring - hair color - professional, detected; Europe; Personal care - hair coloring, and 1 more. Source: EPA CPDat.

Is 2-Aminophenol used in cosmetics?

Yes, 2-Aminophenol is also indexed as a cosmetic ingredient under the name O-Aminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Aminophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Aminophenol have different safety status in cosmetics vs industrial chemicals?

2-Aminophenol is classified GHS CMR hazard (H341, H332, H302) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 2-Aminophenol used outside industrial chemicals?

2-Aminophenol also appears in cosmetics, pharmaceutical databases.