NOAEL Data REACH Registered Cosmetic Ingredient

Benzothiazole

Also known as: 4-27-00-01069, BRN 0109468, EINECS 202-396-2, FEMA No. 3256, FEMA Number 3256 (+3 more)

CAS 95-16-9

Benzothiazole (CAS 95-16-9) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Benzothiazole →

Cross-Vertical Regulatory Divergence

Benzothiazole is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H302, H319, H332).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields

Name

Benzothiazole

CAS Number

95-16-9

DTXSID

DTXSID7024586

Molecular Formula

C7H5NS

InChI Key

IOJUPLGTWVMSFF-UHFFFAOYSA-N

Monoisotopic Mass

135.01427

Synonyms

4-27-00-01069BRN 0109468EINECS 202-396-2FEMA No. 3256FEMA Number 3256USAF EK-4812UNII-G5BW2593EPBT

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records

FragranceFlavouring and nutrientBrightener

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; emissions; Europe; Other indirect contact consumer goods; water	Danish Environmental Protection Agency	Danish EPA
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; Toys and children's products	Scientific Reports	Published Articles
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 12 of 12 studies

Value	Unit	Endpoint	Route	Species	Source
18.9	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
G5BW2593EP	UNII	FDA UNII substance identifier	-	-	openFDA substances
G5BW2593EP	UNII	FDA UNII substance identifier	-	-	openFDA substances
G5BW2593EP	UNII	FDA UNII substance identifier	-	-	openFDA substances
G5BW2593EP	UNII	FDA UNII substance identifier	-	-	openFDA substances
=178	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=257	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=375	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=380	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=479	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
5.1	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 12 of 12 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Benzothiazole	202-396-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BENZO[D]THIAZOLE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Benzothiazole?

Benzothiazole has 12 NOAEL studies in the database. The lowest reported value is 18.9 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Benzothiazole?

Benzothiazole appears on 12 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, air; detected; emissions; Europe; Toys and children's products, air; detected; emissions; Europe; Other indirect contact consumer goods, and 9 more. Source: EPA CPDat.

Is Benzothiazole used in cosmetics?

Yes, Benzothiazole is also indexed as a cosmetic ingredient under the name Benzothiazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Benzothiazole come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Benzothiazole have different safety status in cosmetics vs industrial chemicals?

Benzothiazole is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H302, H319, H332).

Is Benzothiazole used outside industrial chemicals?

Benzothiazole also appears in cosmetics, pharmaceutical, cannabis databases.