What is the NOAEL for 1-Oxaspiro[4.5]decan-2-one, 8-methyl-?
1-Oxaspiro[4.5]decan-2-one, 8-methyl- has 3 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Oxaspiro[4.5]decan-2-one, 8-methyl-
CAS 94201-19-1
1-Oxaspiro[4.5]decan-2-one, 8-methyl- (CAS 94201-19-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for trans-8-Methyl-1-oxaspirodecanone →
SOURCE
noael studies public
NOAEL studies
3
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
1-Oxaspiro[4.5]decan-2-one, 8-methyl-
CAS Number
94201-19-1
DTXSID
DTXSID70888736
Molecular Formula
C10H16O2
InChI Key
COWIMPXRUUJKQF-UHFFFAOYSA-N
Monoisotopic Mass
168.11503
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 3 of 3 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 3 of 3 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 8-methyl-1-oxaspiro[4.5]decan-2-one | 303-602-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 1-Oxaspiro[4.5]decan-2-one, 8-methyl-?
1-Oxaspiro[4.5]decan-2-one, 8-methyl- appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.
Is 1-Oxaspiro[4.5]decan-2-one, 8-methyl- used in cosmetics?
Yes, 1-Oxaspiro[4.5]decan-2-one, 8-methyl- is also indexed as a cosmetic ingredient under the name trans-8-Methyl-1-oxaspirodecanone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Oxaspiro[4.5]decan-2-one, 8-methyl- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 1-Oxaspiro[4.5]decan-2-one, 8-methyl- used outside industrial chemicals?
1-Oxaspiro[4.5]decan-2-one, 8-methyl- also appears in cosmetics databases.