What is the GHS hazard classification for 2-Ethyl-1,3-hexanediol?
2-Ethyl-1,3-hexanediol (CAS 94-96-2) is classified under EU CLP Annex VI as Eye Dam. 1 with signal word Danger. Hazard statements: H318. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethyl-1,3-hexanediol
Also known as: 4-01-00-02597, 6-12 insect repellent, BRN 1735324, Carbide 6-12, Caswell No. 445 (+5 more)
CAS 94-96-2
2-Ethyl-1,3-hexanediol (CAS 94-96-2) is a chemical substance with GHS signal word Danger; key hazard signal: H318. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Ethyl-1,3-hexanediol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
16 fields
Name
2-Ethyl-1,3-hexanediol
CAS Number
94-96-2
DTXSID
DTXSID4025292
Molecular Formula
C8H18O2
InChI Key
RWLALWYNXFYRGW-UHFFFAOYSA-N
Monoisotopic Mass
146.13068
Synonyms
4-01-00-025976-12 insect repellentBRN 1735324Carbide 6-12Caswell No. 445Compound 6-12 insect repellentEINECS 202-377-9EPA Pesticide Chemical Code 0410016-12-Insect repellentUNII-M9JGK7U88V
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Dam. 1 | H318 | GHS05 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
SolventFragranceViscosity modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| M9JGK7U88V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M9JGK7U88V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M9JGK7U88V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M9JGK7U88V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4636 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =9281 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =215 | mg/kg bw/day | LEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =466 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =480 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =932.5 | mg/kg bw/day | NOAEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1884 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| >3768 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =942 | mg/kg bw/day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexane-1,3-diol | 202-377-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ETHOHEXADIOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What is the NOAEL for 2-Ethyl-1,3-hexanediol?
2-Ethyl-1,3-hexanediol has 17 NOAEL studies in the database. The lowest reported value is M9JGK7U88V UNII. Source: openFDA substances.
What regulatory lists include 2-Ethyl-1,3-hexanediol?
2-Ethyl-1,3-hexanediol appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.
Is 2-Ethyl-1,3-hexanediol used in cosmetics?
Yes, 2-Ethyl-1,3-hexanediol is also indexed as a cosmetic ingredient under the name Ethyl Hexanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethyl-1,3-hexanediol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethyl-1,3-hexanediol have different safety status in cosmetics vs industrial chemicals?
2-Ethyl-1,3-hexanediol is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is 2-Ethyl-1,3-hexanediol used outside industrial chemicals?
2-Ethyl-1,3-hexanediol also appears in cosmetics, pharmaceutical databases.