What is the NOAEL for 2-Methoxy-4-methylphenol?
2-Methoxy-4-methylphenol has 24 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methoxy-4-methylphenol
Also known as: BRN 1862340, EINECS 202-252-9, FEMA No. 2671, Homocatechol monomethyl ether, 1-Hydroxy-2-methoxy-4-methylbenzene (+15 more)
CAS 93-51-6
2-Methoxy-4-methylphenol (CAS 93-51-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
2-Methoxy-4-methylphenol
CAS Number
93-51-6
DTXSID
DTXSID6047105
Molecular Formula
C8H10O2
InChI Key
PETRWTHZSKVLRE-UHFFFAOYSA-N
Monoisotopic Mass
138.06808
Synonyms
BRN 1862340EINECS 202-252-9FEMA No. 2671Homocatechol monomethyl ether1-Hydroxy-2-methoxy-4-methylbenzene2-Methoxy-4-cresol4-Methyl guaiacolCresolum drudumRohkcrsolKreosolUNII-W9GW1KZG6N2-Hydroxy-5-methylanisole
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 207.4 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 13.27 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 30.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 46.7 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 159.49 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 280 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 13.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 11.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 5.75 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 8.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 5.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| W9GW1KZG6N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9GW1KZG6N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9GW1KZG6N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9GW1KZG6N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.02 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =740 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methoxy-p-cresol | 202-252-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182715
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methoxy-4-methylphenol?
2-Methoxy-4-methylphenol appears on 6 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is 2-Methoxy-4-methylphenol used in cosmetics?
Yes, 2-Methoxy-4-methylphenol is also indexed as a cosmetic ingredient under the name 2-Methoxy-p-Cresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methoxy-4-methylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Methoxy-4-methylphenol used outside industrial chemicals?
2-Methoxy-4-methylphenol also appears in cosmetics, pharmaceutical, cannabis databases.