What is the NOAEL for 2-Ethoxynaphthalene?
2-Ethoxynaphthalene has 11 NOAEL studies in the database. The lowest reported value is 0.281 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethoxynaphthalene
Also known as: Bromelia, Nerolin, Naphthalene, 2-ethoxy-, Ethyl 2-naphthyl ether, 4-06-00-04257 (+13 more)
CAS 93-18-5
2-Ethoxynaphthalene (CAS 93-18-5) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Ethyl Beta-Naphthyl Ether →
Cross-Vertical Regulatory Divergence
2-Ethoxynaphthalene is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
11
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Chemical inventory jurisdictions
Regulatory lists
6
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
24 fields
Name
2-Ethoxynaphthalene
CAS Number
93-18-5
DTXSID
DTXSID2049684
Molecular Formula
C12H12O
InChI Key
GUMOJENFFHZAFP-UHFFFAOYSA-N
Monoisotopic Mass
172.088815
Synonyms
BromeliaNerolinNaphthalene, 2-ethoxy-Ethyl 2-naphthyl ether4-06-00-04257BRN 2042397EINECS 202-226-7Ethyl beta-naphtholateEthyl beta-naphthyl etherFEMA No. 2768beta-Naphthol ethyl ether2-Naphthol ethyl ether
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
21 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| fracking; water | NY Department of Conservation | CPCat |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.281 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| ZF3IS6G3R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZF3IS6G3R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZF3IS6G3R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZF3IS6G3R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =3110 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 2-naphthyl ether | 202-226-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Ethoxynaphthalene?
2-Ethoxynaphthalene appears on 6 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 3 more. Source: EPA CPDat.
Is 2-Ethoxynaphthalene used in cosmetics?
Yes, 2-Ethoxynaphthalene is also indexed as a cosmetic ingredient under the name Ethyl Beta-Naphthyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethoxynaphthalene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethoxynaphthalene have different safety status in cosmetics vs industrial chemicals?
2-Ethoxynaphthalene is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H411).
Is 2-Ethoxynaphthalene used outside industrial chemicals?
2-Ethoxynaphthalene also appears in cosmetics, food safety, cannabis databases.