What is the NOAEL for 2-Methoxynaphthalene?
2-Methoxynaphthalene has 12 NOAEL studies in the database. The lowest reported value is 6.17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methoxynaphthalene
Also known as: Naphthalene, 2-methoxy-, beta-Methoxynaphthalene, Methyl beta-naphthyl ether, beta-Naphthol mether ether, beta-Naphthol methyl ether (+5 more)
CAS 93-04-9
2-Methoxynaphthalene (CAS 93-04-9) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Methyl Beta-Naphthyl Ether →
Cross-Vertical Regulatory Divergence
2-Methoxynaphthalene is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
2-Methoxynaphthalene
CAS Number
93-04-9
DTXSID
DTXSID7044392
Molecular Formula
C11H10O
InChI Key
LUZDYPLAQQGJEA-UHFFFAOYSA-N
Monoisotopic Mass
158.073165
Synonyms
Naphthalene, 2-methoxy-beta-MethoxynaphthaleneMethyl beta-naphthyl etherbeta-Naphthol mether etherbeta-Naphthol methyl etherbeta-Naphthyl methyl etherEINECS 202-213-6Yara-YaraYura yaraUNII-VX2T1Z50C4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.17 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| VX2T1Z50C4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VX2T1Z50C4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VX2T1Z50C4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VX2T1Z50C4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =12 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl 2-naphthyl ether | 202-213-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL195857
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methoxynaphthalene?
2-Methoxynaphthalene appears on 7 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, Europe, and 4 more. Source: EPA CPDat.
Is 2-Methoxynaphthalene used in cosmetics?
Yes, 2-Methoxynaphthalene is also indexed as a cosmetic ingredient under the name Methyl Beta-Naphthyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methoxynaphthalene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methoxynaphthalene have different safety status in cosmetics vs industrial chemicals?
2-Methoxynaphthalene is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Is 2-Methoxynaphthalene used outside industrial chemicals?
2-Methoxynaphthalene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.