Warning GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4-Hydroxypropylamino-3-nitrophenol

Also known as: UNII-X89W3M6X79, 4-((3-Hydroxypropyl)amino)-3-nitrophenol, Phenol, 4-((3-hydroxypropyl)amino)-3-nitro-, Colorex RBN, Covariane Rouge W 3127 (+4 more)

CAS 92952-81-3

4-Hydroxypropylamino-3-nitrophenol (CAS 92952-81-3) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H411. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 4-Hydroxypropylamino-3-Nitrophenol →

Cross-Vertical Regulatory Divergence

4-Hydroxypropylamino-3-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

4-Hydroxypropylamino-3-nitrophenol

CAS Number

92952-81-3

DTXSID

DTXSID70239209

Molecular Formula

C9H12N2O4

InChI Key

VTXBLQLZQLHDIL-UHFFFAOYSA-N

Monoisotopic Mass

212.079707

Synonyms

UNII-X89W3M6X794-((3-Hydroxypropyl)amino)-3-nitrophenolPhenol, 4-((3-hydroxypropyl)amino)-3-nitro-Colorex RBNCovariane Rouge W 3127HC Red BNPlakatrot Z3-(4-Idrossi-2-nitroanilino)propanolo3-(4-Hydroxy-2-nitroanilino)propanol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Skin Irrit. 2; Aquatic Chronic 2	H315; H411	GHS07; GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 43 of 43 studies

Value	Unit	Endpoint	Route	Species	Source
10	mg/kg bw	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
90	mg/kg bw/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
90	mg/kg bw/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
X89W3M6X79	UNII	FDA UNII substance identifier	-	-	openFDA substances
X89W3M6X79	UNII	FDA UNII substance identifier	-	-	openFDA substances
X89W3M6X79	UNII	FDA UNII substance identifier	-	-	openFDA substances
X89W3M6X79	UNII	FDA UNII substance identifier	-	-	openFDA substances
10	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.02	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=30	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=30	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=30	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=30	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=30	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=30	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=30	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=30	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=90	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=90	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=90	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=90	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=0.02	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.067	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=30	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=30	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=30	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=30	mg/kg	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
90	mg/kg bw/day	developmental toxicity	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30	mg/kg bw/day	genotoxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30	mg/kg bw/day	irritation	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
30	mg/kg bw/day	irritation	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg bw	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 43 of 43 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-[(3-hydroxypropyl)amino]-3-nitrophenol	406-305-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1113/07	18 December 2007	safe	2.6%	secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the GHS hazard classification for 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol (CAS 92952-81-3) is classified under EU CLP Annex VI as Skin Irrit. 2; Aquatic Chronic 2 with signal word Warning. Hazard statements: H315; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol has 43 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 4-Hydroxypropylamino-3-nitrophenol used in cosmetics?

Yes, 4-Hydroxypropylamino-3-nitrophenol is also indexed as a cosmetic ingredient under the name 4-Hydroxypropylamino-3-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Hydroxypropylamino-3-nitrophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Hydroxypropylamino-3-nitrophenol have different safety status in cosmetics vs industrial chemicals?

4-Hydroxypropylamino-3-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).

Is 4-Hydroxypropylamino-3-nitrophenol used outside industrial chemicals?

4-Hydroxypropylamino-3-nitrophenol also appears in cosmetics databases.