Danger GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Ecamsule

Also known as: (E-E )-3,3'-(1,4-Phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid), (+-)-(3E,3'E)-3,3'-(p-Phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid), Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-, 3,3'-(1,4-Phenylenedimethylidyne)bis[7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid], 1,4-Di(2-oxo-10-Sulfo-3-bornylidenemethyl)Benzene (+5 more)

CAS 92761-26-7

Ecamsule (CAS 92761-26-7) is a chemical substance with GHS signal word Danger; key hazard signal: H318. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Terephthalylidene Dicamphor Sulfonic Acid →

Cross-Vertical Regulatory Divergence

Ecamsule is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Ecamsule

CAS Number

92761-26-7

DTXSID

DTXSID80869056

Molecular Formula

C28H34O8S2

InChI Key

HEAHZSUCFKFERC-IWGRKNQJSA-N

Monoisotopic Mass

562.16951

Synonyms

(E-E )-3,3'-(1,4-Phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid)(+-)-(3E,3'E)-3,3'-(p-Phenylenedimethylidyne)bis(2-oxo-10-bornanesulfonic acid)Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-3,3'-(1,4-Phenylenedimethylidyne)bis[7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid]1,4-Di(2-oxo-10-Sulfo-3-bornylidenemethyl)Benzene3,3'-(1,4-Phenylenedimethine)bis(7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic acid1,4-Di(2-oxo-10-sulpho-3-bornylidenemethyl)benzeneTerephthalylidene-3,3'-dicamphor-10,10'-disulfonic acidMexoryl SXELINCS No.: 410-960-6

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Dam. 1	H318	GHS05	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

UV stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Canada; pharmaceutical	DrugBank	DrugBank
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
=29.6	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
M94R1PM439	UNII	FDA UNII substance identifier	-	-	openFDA substances
M94R1PM439	UNII	FDA UNII substance identifier	-	-	openFDA substances
M94R1PM439	UNII	FDA UNII substance identifier	-	-	openFDA substances
M94R1PM439	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	(E-E )-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid)	410-960-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ECAMSULE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Ecamsule?

Ecamsule (CAS 92761-26-7) is classified under EU CLP Annex VI as Eye Dam. 1 with signal word Danger. Hazard statements: H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ecamsule?

Ecamsule has 5 NOAEL studies in the database. The lowest reported value is 29.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Ecamsule?

Ecamsule appears on 2 regulatory/inventory lists including Canada; pharmaceutical, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.

Is Ecamsule used in cosmetics?

Yes, Ecamsule is also indexed as a cosmetic ingredient under the name Terephthalylidene Dicamphor Sulfonic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ecamsule come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Ecamsule have different safety status in cosmetics vs industrial chemicals?

Ecamsule is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.

Is Ecamsule used outside industrial chemicals?

Ecamsule also appears in cosmetics, pharmaceutical databases.