What is the NOAEL for Polyoxyethylene monooctadecyl ether?
Polyoxyethylene monooctadecyl ether has 100 NOAEL studies in the database. The lowest reported value is 22.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Polyoxyethylene monooctadecyl ether
Also known as: Poly(oxy-1,2-ethanediyl), alpha-octadecyl-omega-hydroxy-, Brij S2, 1-Octadecanol, monoether with polyethylene glycol, Poly(oxy-1,2-ethanediyl), .alpha.-octadecyl-.omega.-hydroxy-, alpha-Alkyl-omega-hydroxypoly(oxypropylene) and/or poly(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, minimum number average molecular weight (in amu) 1,100 (+14 more)
CAS 9005-00-9
Polyoxyethylene monooctadecyl ether (CAS 9005-00-9) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Polyoxyethylene monooctadecyl ether is classified GHS Danger (H302, H315, H318, H400, H411, H312, H332) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Polyoxyethylene monooctadecyl ether
CAS Number
9005-00-9
DTXSID
DTXSID7029299
Synonyms
Poly(oxy-1,2-ethanediyl), alpha-octadecyl-omega-hydroxy-Brij S21-Octadecanol, monoether with polyethylene glycolPoly(oxy-1,2-ethanediyl), .alpha.-octadecyl-.omega.-hydroxy-alpha-Alkyl-omega-hydroxypoly(oxypropylene) and/or poly(oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, minimum number average molecular weight (in amu) 1,100Polyethylene glycol stearyl etherBrij 72A 20Stearyl alcohol EOStearyl alcohol ethylene oxideStereal alcohol EOUNII-L0Q8IK9E08
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)EmulsifierCleaning agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =22.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 08Z9G733X6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08Z9G733X6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08Z9G733X6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 08Z9G733X6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10R33Q6723 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10R33Q6723 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10R33Q6723 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10R33Q6723 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 148NZZ5LUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 148NZZ5LUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 148NZZ5LUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 148NZZ5LUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1GDB40D43T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1GDB40D43T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1GDB40D43T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1GDB40D43T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1VBG09S3UL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1VBG09S3UL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1VBG09S3UL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1VBG09S3UL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y50QI1E6X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y50QI1E6X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y50QI1E6X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y50QI1E6X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2819OIV65W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2819OIV65W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2819OIV65W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2819OIV65W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36ALR4705B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36ALR4705B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36ALR4705B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 36ALR4705B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3Q82K3XIGL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3Q82K3XIGL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3Q82K3XIGL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3Q82K3XIGL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4OH5W9UM87 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4OH5W9UM87 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4OH5W9UM87 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4OH5W9UM87 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51J36A59E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51J36A59E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51J36A59E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51J36A59E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 53J3F32P58 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 53J3F32P58 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 53J3F32P58 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 53J3F32P58 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5776GCL1DG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octadecan-1-ol, ethoxylated | 500-017-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emulsifier
Frequently Asked Questions
What regulatory lists include Polyoxyethylene monooctadecyl ether?
Polyoxyethylene monooctadecyl ether appears on 8 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides, inert_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
Is Polyoxyethylene monooctadecyl ether used in cosmetics?
Yes, Polyoxyethylene monooctadecyl ether is also indexed as a cosmetic ingredient under the name Steareth-20. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polyoxyethylene monooctadecyl ether come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Polyoxyethylene monooctadecyl ether have different safety status in cosmetics vs industrial chemicals?
Polyoxyethylene monooctadecyl ether is classified GHS Danger (H302, H315, H318, H400, H411, H312, H332) in the chemicals database but is allowed in EU cosmetics.
Is Polyoxyethylene monooctadecyl ether used outside industrial chemicals?
Polyoxyethylene monooctadecyl ether also appears in cosmetics databases.