Danger GHS07GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

Chymotrypsin

CAS 9004-07-3

Chymotrypsin (CAS 9004-07-3) is a chemical substance with GHS signal word Danger; key hazard signal: H335; H315; H319; H334. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Chymotrypsin →

Cross-Vertical Regulatory Divergence

Chymotrypsin is classified GHS Danger (H335, H315, H319, H334) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 3 fields

Name

Chymotrypsin

CAS Number

9004-07-3

DTXSID

DTXSID901010867

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1	H335; H315; H319; H334	GHS07; GHS08	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies

Value	Unit	Endpoint	Route	Species	Source
BVS505O332	UNII	FDA UNII substance identifier	-	-	openFDA substances
BVS505O332	UNII	FDA UNII substance identifier	-	-	openFDA substances
BVS505O332	UNII	FDA UNII substance identifier	-	-	openFDA substances
BVS505O332	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 4 of 4 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Chymotrypsin	232-671-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL chymotrypsin

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Chymotrypsin?

Chymotrypsin (CAS 9004-07-3) is classified under EU CLP Annex VI as STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1 with signal word Danger. Hazard statements: H335; H315; H319; H334. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Chymotrypsin?

Chymotrypsin has 4 NOAEL studies in the database. The lowest reported value is BVS505O332 UNII. Source: openFDA substances.

What regulatory lists include Chymotrypsin?

Chymotrypsin appears on 3 regulatory/inventory lists including pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, Canada; pharmaceutical. Source: EPA CPDat.

Is Chymotrypsin used in cosmetics?

Yes, Chymotrypsin is also indexed as a cosmetic ingredient under the name Chymotrypsin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Chymotrypsin come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Chymotrypsin have different safety status in cosmetics vs industrial chemicals?

Chymotrypsin is classified GHS Danger (H335, H315, H319, H334) in the chemicals database but is restricted in EU cosmetics.

Is Chymotrypsin used outside industrial chemicals?

Chymotrypsin also appears in cosmetics, pharmaceutical databases.