What is the GHS hazard classification for Alpha-Amylase?
Alpha-Amylase (CAS 9000-90-2) is classified under EU CLP Annex VI as Resp. Sens. 1 with signal word Danger. Hazard statements: H334. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
REACH Registered
Cosmetic Ingredient
Alpha-Amylase
Also known as: EINECS 232-565-6, Pancreatic amylase, alpha Amylase, Amylase, alpha-, Amilosubtilin (+3 more)
CAS 9000-90-2
Alpha-Amylase (CAS 9000-90-2) is a chemical substance with GHS signal word Danger; key hazard signal: H334. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Alpha-Amylase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
35
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chemical inventory jurisdictions
Regulatory lists
3
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eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
11 fields
Name
Alpha-Amylase
CAS Number
9000-90-2
DTXSID
DTXSID4050435
Synonyms
EINECS 232-565-6Pancreatic amylasealpha AmylaseAmylase, alpha-Amilosubtilin1,4-alpha-D-Glucanase1,4-alpha-D-Glucan glucanohydrolaseAttenuzyme Flex
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
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EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Resp. Sens. 1 | H334 | GHS08 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
Cleaning agentChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 35 of 35 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1042je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v1042je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| I909J9CFAT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I909J9CFAT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I909J9CFAT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I909J9CFAT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YOJ58O116E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YOJ58O116E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YOJ58O116E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YOJ58O116E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >20 | mL/kg bw | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =300 | mg/kg bw/day | LOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =150 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =150 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =226 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =226 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =240 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1042je01 |
| =240 | mg/kg bw/day | NOAEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =240 | mg/kg bw/day | NOAEL | oral | Human; Rat | INCHEM_WHO_jecfa_jecmono_v1042je01 |
| =240 | mg/kg bw/day | NOAEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =300 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =300 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =500 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =500 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =600 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =600 | mg/kg bw/day | NOAEL | - | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =1000 | mg/kg bw/day | NOAEL | oral | - | INCHEM_WHO_jecfa_jecmono_v86je01 |
| >=1100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v86je01 |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | INCHEM_WHO_jecfa_jecmono_v86je01 |
Showing 35 of 35 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Amylase, α- | 232-565-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
E1100 — 1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Alpha-Amylase?
Alpha-Amylase has 35 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/day. Source: INCHEM_WHO_jecfa_jecmono_v1042je01.
What regulatory lists include Alpha-Amylase?
Alpha-Amylase appears on 3 regulatory/inventory lists including SCIL (9/2019), Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is Alpha-Amylase used in cosmetics?
Yes, Alpha-Amylase is also indexed as a cosmetic ingredient under the name Amylase. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Amylase come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Alpha-Amylase have different safety status in cosmetics vs industrial chemicals?
Alpha-Amylase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Is Alpha-Amylase used outside industrial chemicals?
Alpha-Amylase also appears in cosmetics, food safety, cannabis databases.