What is the NOAEL for Gluconolactone?
Gluconolactone has 18 NOAEL studies in the database. The lowest reported value is 2 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gluconolactone
Also known as: Glucono delta lactone, Deltagluconolactone, EINECS 202-016-5, Gluconic delta-lactone, D-Gluconic delta-lactone (+14 more)
CAS 90-80-2
Gluconolactone (CAS 90-80-2) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Gluconolactone
CAS Number
90-80-2
DTXSID
DTXSID0026549
Molecular Formula
C6H10O6
InChI Key
PHOQVHQSTUBQQK-SQOUGZDYSA-N
Monoisotopic Mass
178.047738
Synonyms
Glucono delta lactoneDeltagluconolactoneEINECS 202-016-5Gluconic delta-lactoneD-Gluconic delta-lactonedelta-GluconolactoneUNII-WQ29KQ9POT(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one(3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-one(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one1,5-D-gluconolactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
49 records
HumectantSoftener and conditionerChelating agentSolventFragranceAntioxidantPreservativeProcessing aids not otherwise specifiedpH regulating agentChemical reaction regulatorFlavouring and nutrientLeavening agentFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =59 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| WQ29KQ9POT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WQ29KQ9POT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WQ29KQ9POT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WQ29KQ9POT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 560 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| =560 | mg/kg bw/day | NOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| 594 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =594 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 695 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =695 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 780 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| =780 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| - | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | D-glucono-1,5-lactone | 202-016-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLUCONOLACTONE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Gluconolactone?
Gluconolactone appears on 5 regulatory/inventory lists including animal_products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides, and 2 more. Source: EPA CPDat.
Is Gluconolactone used in cosmetics?
Yes, Gluconolactone is also indexed as a cosmetic ingredient under the name Gluconolactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gluconolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Gluconolactone used outside industrial chemicals?
Gluconolactone also appears in cosmetics, pharmaceutical, food safety databases.