Also known as: o-Phenylphenol, [1,1'-Biphenyl]-2-ol, 2-Hydroxybiphenyl, 4-06-00-04579, Biphenyl-2-o1 (+15 more)
CAS 90-43-7
2-Phenylphenol (CAS 90-43-7) is a chemical substance with GHS signal word Danger; key hazard signal: H351; H314; H318; H317; H400; H410. Key regulatory status: California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, EPA TRI.
2-Phenylphenol is classified GHS Danger (H351, H314, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/7 The use of o-phenylphenol as a preservative should be allowed with a maximum concentration of 0,15 % (as phenol) in leave-on and 0,2 % (as phenol) in rinse-off cosmetic products. Contact with eyes should be avoided. The use of sodium o-phenylphenate, potassium o-phenylphenate and MEA o-phenylphenate as preservatives should not be allowed..
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 73 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1B; Aquatic Acute 1; Aquatic Chronic 1 | H351; H314; H318; H317; H400; H410 | GHS08; GHS05; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May be harmful if swallowed Causes skin irritation Causes serious eye irritation May cause respiratory irritation Very toxic to aquatic life |
| Short-term Effects | The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. |
| Long-term Effects | Tumours have been detected in experimental animals but may not be relevant to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; nondetect; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | European Commission | CosIng |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| agricultural; detected; fruits_and_vegetables; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2 | % | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2.5 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | % | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 66 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 67 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 68 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 69 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 70 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 71 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 72 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 73 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 74 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 76 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 92 | mg/kg/day | - | - | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 93 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 94 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 95 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 96 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 97 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| >98 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | % | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | oral | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | oral | rabbit | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 224 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 240 | mg/kg bw/day | - | dermal | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 248 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 248 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 250 | mg/kg bw/d | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| >300 | mg/kg/day | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | - | oral | dog | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 353 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 353 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Biphenyl-2-ol | 201-993-5 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| 2-Phenylphenol | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
E231 — ADI: 0.2 mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →2-Phenylphenol (CAS 90-43-7) is classified under EU CLP Annex VI as Carc. 2; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1B; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H351; H314; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
2-Phenylphenol has 100 NOAEL studies in the database. The lowest reported value is 0.02 mg/kg bw/day. Source: INCHEM_WHO_jmpr_jmpmono_v99pr08.
2-Phenylphenol appears on 9 regulatory/inventory lists including active_ingredient; Pesticides, detected; Europe; Toys and children's products, Europe; nondetect; Toys and children's products, and 6 more. Source: EPA CPDat.
2-Phenylphenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, 2-Phenylphenol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, 2-Phenylphenol is also indexed as a cosmetic ingredient under the name O-PHENYLPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
2-Phenylphenol is classified GHS Danger (H351, H314, H318, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/7 The use of o-phenylphenol as a preservative should be allowed with a maximum concentration of 0,15 % (as phenol) in leave-on and 0,2 % (as phenol) in rinse-off cosmetic products. Contact with eyes should be avoided. The use of sodium o-phenylphenate, potassium o-phenylphenate and MEA o-phenylphenate as preservatives should not be allowed..
2-Phenylphenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.