What is the NOAEL for 2,2,2-Trichloro-1-phenylethyl acetate?
2,2,2-Trichloro-1-phenylethyl acetate has 9 NOAEL studies in the database. The lowest reported value is 11.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2,2-Trichloro-1-phenylethyl acetate
Also known as: BRN 2270144, EINECS 201-972-0, NSC 165582, Rose crystals, Trichlor phenyl methyl carbinyl acetate (+6 more)
CAS 90-17-5
2,2,2-Trichloro-1-phenylethyl acetate (CAS 90-17-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for TRICHLOROMETHYL PHENYL CARBINYL ACETATE →
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
2,2,2-Trichloro-1-phenylethyl acetate
CAS Number
90-17-5
DTXSID
DTXSID2047725
Molecular Formula
C10H9Cl3O2
InChI Key
JKRWZLOCPLZZEI-UHFFFAOYSA-N
Monoisotopic Mass
265.966813
Synonyms
BRN 2270144EINECS 201-972-0NSC 165582Rose crystalsTrichlor phenyl methyl carbinyl acetateTrichloromethyl phenyl carbinyl acetatealpha-(Trichloromethyl)benzenemethanol acetatealpha-(Trichloromethyl)benzyl acetatealpha-(Trichloromethyl)benzyl alcohol acetateTrichloromethylphenylcarbinyl acetateUNII-4VE62Y0O29
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =11.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4VE62Y0O29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4VE62Y0O29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4VE62Y0O29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4VE62Y0O29 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 648 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =6800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2,2-trichloro-1-phenylethyl acetate | 201-972-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183831
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,2,2-Trichloro-1-phenylethyl acetate?
2,2,2-Trichloro-1-phenylethyl acetate appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.
Is 2,2,2-Trichloro-1-phenylethyl acetate used in cosmetics?
Yes, 2,2,2-Trichloro-1-phenylethyl acetate is also indexed as a cosmetic ingredient under the name TRICHLOROMETHYL PHENYL CARBINYL ACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2,2-Trichloro-1-phenylethyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,2,2-Trichloro-1-phenylethyl acetate used outside industrial chemicals?
2,2,2-Trichloro-1-phenylethyl acetate also appears in cosmetics, pharmaceutical databases.