Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

1-Naphthol

Also known as: 1-naphthalenol, NAPHTHOL, CI Oxidation Base 33, EINECS 201-969-4, UNII-2A71EAQ389 (+6 more)

CAS 90-15-3

1-Naphthol (CAS 90-15-3) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H335; H315; H318. Key regulatory status: REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 1-Naphthol →

Cross-Vertical Regulatory Divergence

1-Naphthol is classified GHS Danger (H312, H302, H335, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

1-Naphthol

CAS Number

90-15-3

DTXSID

DTXSID6021793

Molecular Formula

C10H8O

InChI Key

KJCVRFUGPWSIIH-UHFFFAOYSA-N

Monoisotopic Mass

144.057515

Synonyms

1-naphthalenolNAPHTHOLCI Oxidation Base 33EINECS 201-969-4UNII-2A71EAQ389Naphthol-1Naphthyl-1-olTertral ERNalpha-Naphtholalpha-Naphthyl alcoholalpha-hydroxynaphthalene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 ; Acute Tox. 4 ; STOT SE 3; Skin Irrit. 2; Eye Dam. 1	H312; H302; H335; H315; H318	GHS07; GHS05	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 54 records

DyeIntermediateDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care; restricted	European Commission	CosIng
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residue	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
20	mg/kg bw	-	dermal	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
130	mg/kg bw/day	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
130	mg/kg bw	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
41.6250028012423	uM	AC50	-	-	NTP_ICE_endocrine
26.3047473279735	uM	ACC	-	-	NTP_ICE_endocrine
12.7	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
1.4	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
18.3	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
57.2	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=4.58	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
21.8	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
68.2	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
12.4	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
17.4	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
20	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
40.3	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
129.6	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
129.62	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
1.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
1.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
1.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
1.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
2A71EAQ389	UNII	FDA UNII substance identifier	-	-	openFDA substances
2A71EAQ389	UNII	FDA UNII substance identifier	-	-	openFDA substances
2A71EAQ389	UNII	FDA UNII substance identifier	-	-	openFDA substances
2A71EAQ389	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0682	fraction	Fu	-	Human	NTP_ICE_adme_parameters
541	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
1.78	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
1.89	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
>0.42	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=1870	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=2380	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=2590	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
~400	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~600	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0232	unitless	Model Score	-	-	NTP_ICE_endocrine
20	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=20	mg/kg bw	NOAEL	dermal	-	SCCS_vision_codex
=20	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex
=20	mg/kg bw/day	NOAEL	-	rat	SCCNFP_vision_codex
=20	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=20	mg/kg bw	NOAEL	dermal	-	SCCS_vision_codex
=20	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1-naphthol	201-969-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1158/08	15 April 2008	safe	1.0%	sensitisation potential; MoS adequate

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

2.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 1-NAPHTHOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Naphthol?

1-Naphthol (CAS 90-15-3) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H312; H302; H335; H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Naphthol?

1-Naphthol has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 1-Naphthol?

1-Naphthol appears on 10 regulatory/inventory lists including Europe; Personal care; restricted, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, Europe; Personal care - hair coloring, and 7 more. Source: EPA CPDat.

Is 1-Naphthol used in cosmetics?

Yes, 1-Naphthol is also indexed as a cosmetic ingredient under the name 1-Naphthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Naphthol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Naphthol have different safety status in cosmetics vs industrial chemicals?

1-Naphthol is classified GHS Danger (H312, H302, H335, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 1-Naphthol used outside industrial chemicals?

1-Naphthol also appears in cosmetics, pharmaceutical databases.