Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

1-Naphthol

Also known as: 1-naphthalenol, NAPHTHOL, CI Oxidation Base 33, EINECS 201-969-4, UNII-2A71EAQ389 (+6 more)

CAS 90-15-3

1-Naphthol (CAS 90-15-3) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H335; H315; H318. Key regulatory status: REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 1-Naphthol →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
58
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields
Name
1-Naphthol
CAS Number
90-15-3
DTXSID
DTXSID6021793
Molecular Formula
C10H8O
InChI Key
KJCVRFUGPWSIIH-UHFFFAOYSA-N
Monoisotopic Mass
144.057515
Synonyms
1-naphthalenolNAPHTHOLCI Oxidation Base 33EINECS 201-969-4UNII-2A71EAQ389Naphthol-1Naphthyl-1-olTertral ERNalpha-Naphtholalpha-Naphthyl alcoholalpha-hydroxynaphthalene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1H312; H302; H335; H315; H318GHS07; GHS05Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 54 records
DyeIntermediateDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal care; restrictedEuropean CommissionCosIng
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
agricultural; animal_products; detected; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; animal_products; detected; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)
agricultural; detected; fruits_and_vegetables; Pesticides; residueUSDAUnited States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
20mg/kg-oralratUnifiedCodex:SCCNFP:beta.noael_studies
20mg/kg bw-dermal-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
130mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
130mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
41.6250028012423uMAC50--NTP_ICE_endocrine
26.3047473279735uMACC--NTP_ICE_endocrine
12.7ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
1.4ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
18.3ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
57.2ug/mLCV75Dermal-NTP_ICE_skin_sensitization
-uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=4.58mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
21.8%Depletion CysDermal-NTP_ICE_skin_sensitization
68.2%Depletion CysDermal-NTP_ICE_skin_sensitization
12.4%Depletion LysDermal-NTP_ICE_skin_sensitization
17.4%Depletion LysDermal-NTP_ICE_skin_sensitization
20%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
40.3%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
129.6uMEC1.5Dermal-NTP_ICE_skin_sensitization
129.62uMEC1.5Dermal-NTP_ICE_skin_sensitization
1.3%EC3DermalMouseNTP_ICE_skin_sensitization
1.3%EC3DermalMouseNTP_ICE_skin_sensitization
1.3%EC3DermalMouseNTP_ICE_skin_sensitization
1.3%EC3DermalMouseNTP_ICE_skin_sensitization
2A71EAQ389UNIIFDA UNII substance identifier--openFDA substances
2A71EAQ389UNIIFDA UNII substance identifier--openFDA substances
2A71EAQ389UNIIFDA UNII substance identifier--openFDA substances
2A71EAQ389UNIIFDA UNII substance identifier--openFDA substances
0.0682fractionFu-HumanNTP_ICE_adme_parameters
541uMIC50Dermal-NTP_ICE_skin_sensitization
1.78ratioImaxDermal-NTP_ICE_skin_sensitization
1.89ratioImaxDermal-NTP_ICE_skin_sensitization
>0.42mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=1870mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=2380mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=2590mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1000mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
100mg/kg bw/dayLOAELoralratCOSMOS_DB
~400mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
~600mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=1mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
-unitlessModel Score--NTP_ICE_endocrine
0.0232unitlessModel Score--NTP_ICE_endocrine
20mg/kg bw/dayNOAELoralratCOSMOS_DB
=20mg/kg bwNOAELdermal-SCCS_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCNFP_vision_codex
=20mg/kgNOAELoralratSCCNFP_vision_codex
=20mg/kg bwNOAELdermal-SCCS_vision_codex
=20mg/kg bw/dayNOAEL-humanSCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1-naphthol201-969-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1158/0815 April 2008safe1.0%sensitisation potential; MoS adequate

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
2.0%
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 1-NAPHTHOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Naphthol?

1-Naphthol (CAS 90-15-3) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H312; H302; H335; H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Naphthol?

1-Naphthol has 100 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 1-Naphthol?

1-Naphthol appears on 10 regulatory/inventory lists including Europe; Personal care; restricted, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, Europe; Personal care - hair coloring, and 7 more. Source: EPA CPDat.

Is 1-Naphthol used in cosmetics?

Yes, 1-Naphthol is also indexed as a cosmetic ingredient under the name 1-Naphthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Naphthol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Naphthol have different safety status in cosmetics vs industrial chemicals?

1-Naphthol is classified GHS Danger (H312, H302, H335, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 1-Naphthol used outside industrial chemicals?

1-Naphthol also appears in cosmetics, pharmaceutical databases.