Also known as: o-Methoxyphenol, Guaiacol, EINECS 201-964-7, FEMA No. 2532, Guajacol (+13 more)
CAS 90-05-1
2-Methoxyphenol (CAS 90-05-1) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H315; H319. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2 | H302; H315; H319 | GHS07 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 44.9 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 6JKA7MAH9C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6JKA7MAH9C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6JKA7MAH9C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6JKA7MAH9C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.569 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 42 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 15.7 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 36.1 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 37.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 59 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 69 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 81.8 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 83.7 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 98.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 109.5 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 4.9 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 7.3 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 35.5 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 49.9 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 64.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 28 of 28 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Guaiacol | 201-964-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →2-Methoxyphenol (CAS 90-05-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H315; H319. Source: EU CLP Annex VI (ECHA).
2-Methoxyphenol has 28 NOAEL studies in the database. The lowest reported value is 44.9 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
2-Methoxyphenol appears on 12 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, artificial_saliva; detected; emissions; Europe; Toys and children's products, and 9 more. Source: EPA CPDat.
Yes, 2-Methoxyphenol is also indexed as a cosmetic ingredient under the name Guaiacol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
2-Methoxyphenol also appears in cosmetics, pharmaceutical, cannabis databases.