What is the NOAEL for Salicylaldehyde?
Salicylaldehyde has 21 NOAEL studies in the database. The lowest reported value is 0.164 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Salicylaldehyde
Also known as: 2-Hydroxy-benzaldehyde, 4-08-00-00176, Benzaldehyde, o-hydroxy-, BRN 0471388, EINECS 201-961-0 (+6 more)
CAS 90-02-8
Salicylaldehyde (CAS 90-02-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Salicylaldehyde is classified GHS Danger (H302, H312, H315, H319, H341, H227, H311, H361) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
21
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Salicylaldehyde
CAS Number
90-02-8
DTXSID
DTXSID1021792
Molecular Formula
C7H6O2
InChI Key
SMQUZDBALVYZAC-UHFFFAOYSA-N
Monoisotopic Mass
122.036779
Synonyms
2-Hydroxy-benzaldehyde4-08-00-00176Benzaldehyde, o-hydroxy-BRN 0471388EINECS 201-961-0FEMA No. 3004SalicyladehydeUNII-17K64GZH20FEMA 3004Salicylaldehyde, 8CISalizylaldehyd
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 58.3315401426754 | uM | AC50 | - | - | NTP ICE endocrine |
| 50.401362189763 | uM | ACC | - | - | NTP ICE endocrine |
| =0.164 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 17K64GZH20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 17K64GZH20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 17K64GZH20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 17K64GZH20 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =520 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| ~500 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0288 | unitless | Model Score | - | - | NTP ICE endocrine |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =10 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =40 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| =160 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Salicylaldehyde | 201-961-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
SALICYLADEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Salicylaldehyde?
Salicylaldehyde appears on 6 regulatory/inventory lists including detected; emissions; Europe; Other indirect contact consumer goods; water, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is Salicylaldehyde used in cosmetics?
Yes, Salicylaldehyde is also indexed as a cosmetic ingredient under the name Salicylaldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Salicylaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Salicylaldehyde have different safety status in cosmetics vs industrial chemicals?
Salicylaldehyde is classified GHS Danger (H302, H312, H315, H319, H341, H227, H311, H361) in the chemicals database but is restricted in EU cosmetics.
Is Salicylaldehyde used outside industrial chemicals?
Salicylaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.