What is the NOAEL for (-)-Isopulegol?
(-)-Isopulegol has 18 NOAEL studies in the database. The lowest reported value is 3TH92O3BXN UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(-)-Isopulegol
Also known as: EINECS 201-940-6, FEMA No. 2962, p-Menth-8-en-3-ol, (1R,3R,4S)-(-)-, p-8(9)-Menthen-3-ol, 5-Methyl-2-(1-methylethenyl)cyclohexanol, (1R-(1alpha,2beta,5alpha))- (+5 more)
CAS 89-79-2
(-)-Isopulegol (CAS 89-79-2) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
(-)-Isopulegol is classified GHS Danger (H302, H315, H319, H351, H372, H226, H318) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
(-)-Isopulegol
CAS Number
89-79-2
DTXSID
DTXSID5047116
Molecular Formula
C10H18O
InChI Key
ZYTMANIQRDEHIO-UTLUCORTSA-N
Monoisotopic Mass
154.135765
Synonyms
EINECS 201-940-6FEMA No. 2962p-Menth-8-en-3-ol, (1R,3R,4S)-(-)-p-8(9)-Menthen-3-ol5-Methyl-2-(1-methylethenyl)cyclohexanol, (1R-(1alpha,2beta,5alpha))-l-Isopulegoliso-Pulegol(-)-L-IsopulegolUNII-3TH92O3BXNIsopulegol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3TH92O3BXN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3TH92O3BXN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3TH92O3BXN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3TH92O3BXN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =38 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =38 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =38 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.000033 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =0.000033 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =0.44 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =0.44 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =20 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =20 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =40 | mg/kg bw/day | NOEL | - | Human | INCHEM_WHO_jecfa_jecmono_v46je10 |
| =40 | mg/kg bw/day | NOEL | - | Human | INCHEM_WHO_jecfa_jecmono_v46je10 |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isopulegol | 201-940-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOPULEGOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (-)-Isopulegol?
(-)-Isopulegol appears on 7 regulatory/inventory lists including active_ingredient; Europe; Pesticides, detected; Europe; Personal care - sexual wellness, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is (-)-Isopulegol used in cosmetics?
Yes, (-)-Isopulegol is also indexed as a cosmetic ingredient under the name Isopulegol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (-)-Isopulegol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does (-)-Isopulegol have different safety status in cosmetics vs industrial chemicals?
(-)-Isopulegol is classified GHS Danger (H302, H315, H319, H351, H372, H226, H318) in the chemicals database but is restricted in EU cosmetics.
Is (-)-Isopulegol used outside industrial chemicals?
(-)-Isopulegol also appears in cosmetics, pharmaceutical, cannabis databases.