NOAEL Data REACH Registered Cosmetic Ingredient

Dl-Menthol

Also known as: Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-, 2-06-00-00052, 4-06-00-00151, BRN 1902288, BRN 3194263 (+15 more)

CAS 89-78-1

Dl-Menthol (CAS 89-78-1) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Menthol →

SOURCE noael studies public
NOAEL studies
34
SOURCE chemical inventory jurisdictions
Regulatory lists
9
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Dl-Menthol
CAS Number
89-78-1
DTXSID
DTXSID1020805
Molecular Formula
C10H20O
InChI Key
NOOLISFMXDJSKH-KXUCPTDWSA-N
Monoisotopic Mass
156.151415
Synonyms
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-2-06-00-000524-06-00-00151BRN 1902288BRN 3194263EINECS 201-939-0EINECS 239-388-3Headache crystals(+-)-MentholMenthol naturalMenthol natural, brazilianMenthol racemic

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
SCIL (9/2019)USEPASafer Chemical Ingredients List
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies
ValueUnitEndpointRouteSpeciesSource
range:0-0.20.2mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v042je21
range:0-0.20.2mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v042je21
range:0-44mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v042je21
range:0-44mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v042je21
YS08XHA860UNIIFDA UNII substance identifier--openFDA substances
YS08XHA860UNIIFDA UNII substance identifier--openFDA substances
YS08XHA860UNIIFDA UNII substance identifier--openFDA substances
YS08XHA860UNIIFDA UNII substance identifier--openFDA substances
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
5184ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
-unitlessModel Score--NTP_ICE_endocrine
>667mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
>740mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
>937mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1250mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
>1440mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1477.5mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=0.017mg/kg bw/dayNOEL--INCHEM_WHO_jecfa_jecmono_v042je21
=0.017mg/kg bw/dayNOEL--INCHEM_WHO_jecfa_jecmono_v042je21
=0.19%NOELoralMouseToxValDB_ECOTOX
=0.36%NOELoralMouseToxValDB_ECOTOX
=0.7%NOELoralRatToxValDB_ECOTOX
=50mg/kg bw/dayNOEL--INCHEM_WHO_jecfa_jecmono_v042je21
=50mg/kg bw/dayNOEL--INCHEM_WHO_jecfa_jecmono_v042je21
=185mg/kg bw/dayNOELoralMouseToxValDB_ECHA_IUCLID
=218mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
=400mg/kg bw/dayNOEL-RatINCHEM_WHO_jecfa_jecmono_v042je21
=400mg/kg bw/dayNOEL-RatINCHEM_WHO_jecfa_jecmono_v042je21
=405mg/kg bw/dayNOELoralHamsterToxValDB_ECHA_IUCLID
=425mg/kg bw/dayNOELoralRabbitToxValDB_ECHA_IUCLID
=1450mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
3unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization
4000ppmTop dose-MouseNTP_ICE_cancer
7500ppmTop dose-RatNTP_ICE_cancer

Showing 34 of 34 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredMenthol201-939-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
No specific Annex III limit for scalp/shampoo use at standard concentrations (typically ≤1%); higher concentrations require safety assessment
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL LEVOMENTHOL
ChEMBL Phase
3
Adverse Events
59
Bioactivity
9
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-4 mg/kg bw mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Dl-Menthol?

Dl-Menthol has 34 NOAEL studies in the database. The lowest reported value is 0.2 mg/kg bw/day. Source: INCHEM_WHO_jecfa_jecmono_v042je21.

What regulatory lists include Dl-Menthol?

Dl-Menthol appears on 7 regulatory/inventory lists including active_ingredient; Europe; Pesticides, detected; drinking_water; MN Chemical Screening, Europe; Other direct contact consumer goods, and 4 more. Source: EPA CPDat.

Is Dl-Menthol used in cosmetics?

Yes, Dl-Menthol is also indexed as a cosmetic ingredient under the name Menthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dl-Menthol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Dl-Menthol used outside industrial chemicals?

Dl-Menthol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.