NOAEL Data REACH Registered Cosmetic Ingredient

L-Tartaric acid

Also known as: L-(+)-Tartaric acid, d-alpha,beta-Dihydroxysuccinic acid, EINECS 201-766-0, Kyselina 2,3-dihydroxybutandiova, Kyselina vinna (+15 more)

CAS 87-69-4

L-Tartaric acid (CAS 87-69-4) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tartaric Acid →

SOURCE noael studies public
NOAEL studies
46
SOURCE chemical inventory jurisdictions
Regulatory lists
16
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
L-Tartaric acid
CAS Number
87-69-4
DTXSID
DTXSID8023632
Molecular Formula
C4H6O6
InChI Key
FEWJPZIEWOKRBE-JCYAYHJZSA-N
Monoisotopic Mass
150.016438
Synonyms
L-(+)-Tartaric acidd-alpha,beta-Dihydroxysuccinic acidEINECS 201-766-0Kyselina 2,3-dihydroxybutandiovaKyselina vinnaUNII-W4888I119H(+)-Weinsaeure(+)-tartarate(1R,2R)-1,2-Dihydroxyethane-1,2-dicarboxylic acid(2R,3R)-2,3-Dihydroxybernsteinsaeure(2R,3R)-2,3-dihydroxybutanedioate(2R,3R)-2,3-tartaric acid

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 37 records
pH regulating agentDeodorizerFragranceAnti-streaking agentProcessing aids not otherwise specifiedHumectantFlavouring and nutrientDrierLeavening agentStabilizing agentAnti-caking agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records
ListKeywordSource
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
IFRA TransparencyIFRAIFRA
consumer_productP&GProctor & Gamble
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
animal_productsUSDAUnited States Department of Agriculture (USDA)
SCIL (9/2019)USEPASafer Chemical Ingredients List
consumer_productP&GProctor & Gamble
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 46 of 46 studies
ValueUnitEndpointRouteSpeciesSource
<=30mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
<=30mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=30mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=240mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=240mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
>1050.602ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
416.7ug/mLCV75Dermal-NTP_ICE_skin_sensitization
3.8%Depletion CysDermal-NTP_ICE_skin_sensitization
6.6%Depletion CysDermal-NTP_ICE_skin_sensitization
-2%Depletion LysDermal-NTP_ICE_skin_sensitization
1.2%Depletion LysDermal-NTP_ICE_skin_sensitization
2.3%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
2.5%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
3uMEC1.5Dermal-NTP_ICE_skin_sensitization
>2000uMEC1.5Dermal-NTP_ICE_skin_sensitization
W4888I119HUNIIFDA UNII substance identifier--openFDA substances
W4888I119HUNIIFDA UNII substance identifier--openFDA substances
W4888I119HUNIIFDA UNII substance identifier--openFDA substances
W4888I119HUNIIFDA UNII substance identifier--openFDA substances
70.2uMIC50Dermal-NTP_ICE_skin_sensitization
>2400uMIC50Dermal-NTP_ICE_skin_sensitization
1.2ratioImaxDermal-NTP_ICE_skin_sensitization
1.277ratioImaxDermal-NTP_ICE_skin_sensitization
15.3ratioImaxDermal-NTP_ICE_skin_sensitization
>2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
<5000mg/kg bwLD50oralRatNTP_ICE_acute_oral
~181mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=310mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=2800mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
~3606mg/kg bw/dayLELoralMouseToxValDB_ECHA_IUCLID
~5000mg/kg bw/dayLELoralRabbitToxValDB_ECHA_IUCLID
~10000mg/kg bw/dayLELoralCatToxValDB_ECHA_IUCLID
-unitlessModel Score--NTP_ICE_endocrine
181mg/kg bw/dayNOAELoralratCOSMOS_DB
215mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
225mg/kg bw/dayNOAELoralhamsterCOSMOS_DB
~225mg/kg bw/dayNOAELoralHamsterToxValDB_ECHA_IUCLID
274mg/kg bw/dayNOAELoralmouseCOSMOS_DB
~274mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
990mg/kg bw/dayNOAELoraldogCOSMOS_DB
1200mg/kg bw/dayNOAELoralratCOSMOS_DB
~3000mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=3100mg/kg bw/dayNOAELoralRatToxValDB_EFSA
=3100mg/kg bw/dayNOAELoral: feedRatEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=3100mg/kg bw/dayNOAELoral: feedRatEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=96mg/LNOELoralMouseToxValDB_ECOTOX

Showing 46 of 46 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered(+)-tartaric acid201-766-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
pH-adjuster
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL TARTARIC ACID
ChEMBL Phase
4
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E334 — ADI: 30 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for L-Tartaric acid?

L-Tartaric acid has 46 NOAEL studies in the database. The lowest reported value is -2 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include L-Tartaric acid?

L-Tartaric acid appears on 14 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, consumer_product, and 11 more. Source: EPA CPDat.

Is L-Tartaric acid used in cosmetics?

Yes, L-Tartaric acid is also indexed as a cosmetic ingredient under the name Tartaric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for L-Tartaric acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does L-Tartaric acid have different safety status in cosmetics vs industrial chemicals?

L-Tartaric acid is classified GHS Danger (H302, H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Is L-Tartaric acid used outside industrial chemicals?

L-Tartaric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.