Danger GHS08GHS09 NOAEL Data IARC Group 3 SVHC Prop 65 REACH Registered Cosmetic Ingredient

Benzyl butyl phthalate

Also known as: 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester, Benzyl butylphthalate, BRN 2062204, Butyl phenylmethyl 1,2-benzenedicarboxylate, Caswell No. 125G (+8 more)

CAS 85-68-7

Benzyl butyl phthalate (CAS 85-68-7) is a chemical substance with GHS signal word Danger; key hazard signal: H360Df; H400; H410. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC.

View cosmetic safety profile for Butyl Benzyl Phthalate (BBP) →

Cross-Vertical Regulatory Divergence

Benzyl butyl phthalate is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

Benzyl butyl phthalate

CAS Number

85-68-7

DTXSID

DTXSID3020205

Molecular Formula

C19H20O4

InChI Key

IRIAEXORFWYRCZ-UHFFFAOYSA-N

Monoisotopic Mass

312.136159

Synonyms

1,2-Benzenedicarboxylic acid, butyl phenylmethyl esterBenzyl butylphthalateBRN 2062204Butyl phenylmethyl 1,2-benzenedicarboxylateCaswell No. 125GEINECS 201-622-7NCI-C54375Benzyl-butylester kyseliny ftaloveUNII-YPC4PJX59MBzBPBBPSant 160

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1998	Sup 7, 73

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA (EU) 1 records

Substance	Reason	Included
Benzyl butyl phthalate (BBP)	Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - human health)	28-Oct-2008

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	developmental	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 1B; Aquatic Acute 1; Aquatic Chronic 1	H360Df; H400; H410	GHS08; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Long-term Effects	Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 33 records

PlasticizerProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
Construction and building materials; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; New Zealand; Toys and children's products	International Journal of Environmental Research and Public Health	Published Articles
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected	Springer	Published Articles
detected; Toys and children's products	Environmental Monitoring and Assessment	Published Articles
Europe; nondetect; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
banned; Europe	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe; soil	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
children; Europe	Danish Environmental Protection Agency	Danish EPA
Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
nondetect; Other direct contact consumer goods; Toys and children's products	Reproductive Toxicology	Published Articles
banned; Europe; Personal care	European Commission	CosIng
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; emissions; Europe; Other indirect contact consumer goods; water	Danish Environmental Protection Agency	Danish EPA
detected; emissions; Europe; Other indirect contact consumer goods; water	Danish Environmental Protection Agency	Danish EPA
pharmaceutical	US International Trade Commission	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
12.9441187605648	uM	AC50	-	-	NTP_ICE_endocrine
2511.89	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
4270	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
13000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
36000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
89200	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
101000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
7.41251839025667	uM	ACC	-	-	NTP_ICE_endocrine
1000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
ABoral=1200	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABoral=1200	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABoral=1200	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
359	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
427	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=4.36	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
3.6	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
0.1	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
9.834	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
1980	nM	EC50	-	-	NTP_ICE_endocrine
YPC4PJX59M	UNII	FDA UNII substance identifier	-	-	openFDA substances
YPC4PJX59M	UNII	FDA UNII substance identifier	-	-	openFDA substances
YPC4PJX59M	UNII	FDA UNII substance identifier	-	-	openFDA substances
YPC4PJX59M	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.00000322	fraction	Fu	-	Human	NTP_ICE_adme_parameters
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
<1000	nM	IC20	-	-	NTP_ICE_endocrine
2900	nM	IC20	-	-	NTP_ICE_endocrine
>10000	nM	IC20	-	-	NTP_ICE_endocrine
4000	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
2.992	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
=120	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=120	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=180	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=180	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344/N)	ToxRefDB_ToxRefDB_v3_pod.csv
=300	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
501.2	nM	LEL	-	-	NTP_ICE_endocrine
=900	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=900	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
>1250	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
>1250	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=153309	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=200	mg/kg bw/day	LOAEL	oral	Rat	INCHEM_WHO_cicads_cicads_cicad17
=224	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_HPVIS
=312.5	mg/kg bw/day	LOAEL	oral	Rat	INCHEM_WHO_cicads_cicads_cicad17
=360	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_HPVIS
=381	mg/kg bw	LOAEL	oral	-	INCHEM_WHO_cicads_cicads_cicad17

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Benzyl butyl phthalate	201-622-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. additional information becoming available on the adverse health effects of BBP; b. BBP being used in toys and childcare articles at a concentration of >0.5 %; c. additional sources of potentially high public exposure to BBP other than toys and childcare articles being identified; d. additional information or events that change the assumptions in estimating the cumulative risks in this assessment. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1450327

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 500 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Benzyl butyl phthalate?

Benzyl butyl phthalate (CAS 85-68-7) is classified under EU CLP Annex VI as Repr. 1B; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360Df; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Benzyl butyl phthalate?

Benzyl butyl phthalate has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Benzyl butyl phthalate?

Benzyl butyl phthalate appears on 37 regulatory/inventory lists including Construction and building materials; detected; Europe, detected; Europe; Furniture and Furnishings, Europe; nondetect; Other indirect contact consumer goods, and 34 more. Source: EPA CPDat.

Is Benzyl butyl phthalate a carcinogen according to IARC?

Benzyl butyl phthalate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Benzyl butyl phthalate on the California Proposition 65 list?

Yes, Benzyl butyl phthalate is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

Is Benzyl butyl phthalate a Substance of Very High Concern (SVHC)?

Yes, Benzyl butyl phthalate is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.

Is Benzyl butyl phthalate used in cosmetics?

Yes, Benzyl butyl phthalate is also indexed as a cosmetic ingredient under the name Butyl Benzyl Phthalate (BBP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Benzyl butyl phthalate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Benzyl butyl phthalate have different safety status in cosmetics vs industrial chemicals?

Benzyl butyl phthalate is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H400, H410).

Is Benzyl butyl phthalate used outside industrial chemicals?

Benzyl butyl phthalate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.