What is the NOAEL for Itraconazole?
Itraconazole has 6 NOAEL studies in the database. The lowest reported value is 304NUG5GF4 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Itraconazole
Also known as: BRN 6042047, Itraconazol, Itraconazolum, Hyphanox, Candistat (+2 more)
CAS 84625-61-6
Itraconazole (CAS 84625-61-6) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Itraconazole is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Itraconazole
CAS Number
84625-61-6
DTXSID
DTXSID3023180
Molecular Formula
C35H38Cl2N8O4
InChI Key
VHVPQPYKVGDNFY-ZPGVKDDISA-N
Monoisotopic Mass
704.239307
Synonyms
BRN 6042047ItraconazolItraconazolumHyphanoxCandistatItrizole (TN)Sporanox (TN)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 304NUG5GF4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 304NUG5GF4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 304NUG5GF4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 304NUG5GF4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.002 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >320 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ITRACONAZOLE
ChEMBL Phase
4
Adverse Events
1200
Bioactivity
24
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Itraconazole?
Itraconazole appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Itraconazole used in cosmetics?
Yes, Itraconazole is also indexed as a cosmetic ingredient under the name Itraconazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Itraconazole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Itraconazole have different safety status in cosmetics vs industrial chemicals?
Itraconazole is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335).
Is Itraconazole used outside industrial chemicals?
Itraconazole also appears in cosmetics, pharmaceutical, cannabis databases.