What is the NOAEL for Rosmarinus officinalis leaf extract?
Rosmarinus officinalis leaf extract has 8 NOAEL studies in the database. The lowest reported value is 14.69 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Rosmarinus officinalis leaf extract
CAS 84604-14-8
Rosmarinus officinalis leaf extract (CAS 84604-14-8) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Rosemary Extract (Rosmarinus Officinalis Leaf Extract) →
Cross-Vertical Regulatory Divergence
Rosmarinus officinalis leaf extract is classified GHS Danger (H226, H304, H317, H332, H371, H373, H411) in the chemicals database but is allowed in EU cosmetics at max 0.2%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
16
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
3 fields
Name
Rosmarinus officinalis leaf extract
CAS Number
84604-14-8
DTXSID
DTXSID001015096
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
BiocideAntioxidantDeodorizerHumectantSoftener and conditionerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care - body oil | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =14.69 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| IJ67X351P9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IJ67X351P9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IJ67X351P9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IJ67X351P9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 130 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Rosemary, ext. | 283-291-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.2%
Category
fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E392 — ADI: Temporary ADI of 0–0.3 mg/kg bw (expressed as carnosic acid and carnosol) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Rosmarinus officinalis leaf extract?
Rosmarinus officinalis leaf extract appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; Personal care - body oil, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 3 more. Source: EPA CPDat.
Is Rosmarinus officinalis leaf extract used in cosmetics?
Yes, Rosmarinus officinalis leaf extract is also indexed as a cosmetic ingredient under the name Rosemary Extract (Rosmarinus Officinalis Leaf Extract). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Rosmarinus officinalis leaf extract come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Rosmarinus officinalis leaf extract have different safety status in cosmetics vs industrial chemicals?
Rosmarinus officinalis leaf extract is classified GHS Danger (H226, H304, H317, H332, H371, H373, H411) in the chemicals database but is allowed in EU cosmetics at max 0.2%.
Is Rosmarinus officinalis leaf extract used outside industrial chemicals?
Rosmarinus officinalis leaf extract also appears in cosmetics, food safety, cannabis databases.