What is the NOAEL for Alpha-Arbutin?
Alpha-Arbutin has 100 NOAEL studies in the database. The lowest reported value is 2 %. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Alpha-Arbutin
Also known as: UNII-72VUP07IT5
CAS 84380-01-8
Alpha-Arbutin (CAS 84380-01-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
7 fields
Name
Alpha-Arbutin
CAS Number
84380-01-8
DTXSID
DTXSID20233358
Molecular Formula
C12H16O7
InChI Key
BJRNKVDFDLYUGJ-ZIQFBCGOSA-N
Monoisotopic Mass
272.089603
Synonyms
UNII-72VUP07IT5
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
AntioxidantSoftener and conditionerBleaching agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 9 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =15 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =20 | mg/kg/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 20 | mg/kg bw/day | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =20 | mg/kg/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =74 | mg/kg/day | - | dermal | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 344 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 72VUP07IT5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 72VUP07IT5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 72VUP07IT5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2 | % | NOAEL | - | - | SCCS_vision_codex |
| =2 | % | NOAEL | - | - | SCCS_vision_codex |
| =2 | % | NOAEL | - | - | SCCS_vision_codex |
| =2 | % | NOAEL | - | - | SCCS_vision_codex |
| =3.3 | - | NOAEL | oral | guinea pig | SCCS_vision_codex |
| =3.3 | - | NOAEL | oral | guinea pig | SCCS_vision_codex |
| =3.3 | - | NOAEL | oral | guinea pig | SCCS_vision_codex |
| =3.3 | - | NOAEL | oral | guinea pig | SCCS_vision_codex |
| =9 | - | NOAEL | - | - | SCCS_vision_codex |
| =9 | - | NOAEL | - | - | SCCS_vision_codex |
| =9 | - | NOAEL | - | - | SCCS_vision_codex |
| =9 | - | NOAEL | - | - | SCCS_vision_codex |
| =15 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =15 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =15 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =15 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =15 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =15 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =20 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =20 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =20 | % | NOAEL | dermal | guinea pig | SCCS_vision_codex |
| =20 | mg/kg bw/d | NOAEL | - | - | SCCS_vision_codex |
| =20 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =20 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =20 | % | NOAEL | dermal | guinea pig | SCCS_vision_codex |
| =20 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =20 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =20 | mg/kg bw | NOAEL | oral | - | SCCS_vision_codex |
| =20 | % | NOAEL | dermal | guinea pig | SCCS_vision_codex |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-hydroxyphenyl-alpha-D-glucopyranoside | 440-470-8 | ECHA overview → |
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1552/15 | 27 May 2015 | safe with restrictions | 2% face cream; 0.5% body lotion | Hydroquinone release potential; limited data on other product types; precursor to updated SCCS/1642/22 |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
2% face / 0.5% body
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL226495
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Alpha-Arbutin?
Alpha-Arbutin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Alpha-Arbutin used in cosmetics?
Yes, Alpha-Arbutin is also indexed as a cosmetic ingredient under the name Alpha-Arbutin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Alpha-Arbutin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Alpha-Arbutin used outside industrial chemicals?
Alpha-Arbutin also appears in cosmetics, pharmaceutical databases.