What is the NOAEL for Phytonadione?
Phytonadione has 5 NOAEL studies in the database. The lowest reported value is S5Z3U87QHF UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Phytonadione
Also known as: Phylloquinone, K1, EINECS 201-564-2, 1,4-Naphthoquinone, 2-methyl-3-phytyl-, UNII-S5Z3U87QHF, 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione (+15 more)
CAS 84-80-0
Phytonadione (CAS 84-80-0) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Phytonadione
CAS Number
84-80-0
DTXSID
DTXSID8023472
Molecular Formula
C31H46O2
InChI Key
MBWXNTAXLNYFJB-NKFFZRIASA-N
Monoisotopic Mass
450.349781
Synonyms
Phylloquinone, K1EINECS 201-564-21,4-Naphthoquinone, 2-methyl-3-phytyl-UNII-S5Z3U87QHF2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione2-Methyl-3-phythyl-1,4-naphthochinon2-Methyl-3-phytyl-1,4-naphthochinon2-Methyl-3-phytyl-1,4-napthoquinone2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione3-Phytylmenadione
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| S5Z3U87QHF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5Z3U87QHF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5Z3U87QHF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S5Z3U87QHF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >33487 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1393/10 | 23 March 2010 | safe with restrictions | 1% in cosmetic products | Anticoagulant mechanism; cosmetic use at 1% considered safe based on low dermal absorption and systemic availability |
| SCCP/1157/08 | 24 June 2008 | safe with restrictions | 1% in cosmetic products | Low systemic availability from skin; anticoagulant activity of concern at higher doses |
| SCCP/1136/07 | 28 September 2007 | safe with restrictions | 1% | Confirmed safe at 1%; low dermal absorption |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHYTONADIONE
ChEMBL Phase
4
Adverse Events
161
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Phytonadione?
Phytonadione appears on 3 regulatory/inventory lists including Canada; pharmaceutical, pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue. Source: EPA CPDat.
Is Phytonadione used in cosmetics?
Yes, Phytonadione is also indexed as a cosmetic ingredient under the name Phytonadione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phytonadione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Phytonadione used outside industrial chemicals?
Phytonadione also appears in cosmetics, pharmaceutical, food safety databases.