Danger GHS08GHS09 NOAEL Data SVHC Prop 65 REACH Registered Cosmetic Ingredient

1,2-Benzenedicarboxylic acid, dibutyl ester

Also known as: Di-n-butylorthophthalate, Dibutyl phthalate, o-Benzenedicarboxylic acid, dibutyl ester, BRN 1914064, N-Butylphthalate (+14 more)

CAS 84-74-2

1,2-Benzenedicarboxylic acid, dibutyl ester (CAS 84-74-2) is a chemical substance with GHS signal word Danger; key hazard signal: H360Df; H400. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Dibutyl Phthalate (DBP) →

Cross-Vertical Regulatory Divergence

1,2-Benzenedicarboxylic acid, dibutyl ester is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H400).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

1,2-Benzenedicarboxylic acid, dibutyl ester

CAS Number

84-74-2

DTXSID

DTXSID2021781

Molecular Formula

C16H22O4

InChI Key

DOIRQSBPFJWKBE-UHFFFAOYSA-N

Monoisotopic Mass

278.151809

Synonyms

Di-n-butylorthophthalateDibutyl phthalateo-Benzenedicarboxylic acid, dibutyl esterBRN 1914064N-ButylphthalateCaswell No. 292EINECS 201-557-4EPA Pesticide Chemical Code 028001Ersoplast FDAHatcol DBPPhthalate, dibutyl-Phthalate, di-n-butyl

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA (EU) 1 records

Substance	Reason	Included
Dibutyl phthalate (DBP)	Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health)	28-Oct-2008

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	developmental, female, male	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 1B; Aquatic Acute 1	H360Df; H400	GHS08; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Long-term Effects	Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	5 mg/m³	-	5	N
NIOSH	TWA	5 mg/m³	-	5	N
ACGIH	TWA	5 mg/m³ [1990]	-	5	N
CAL/OSHA	TWA	5 mg/m³	-	5	N
NIOSH	IDLH	4000 mg/m³	-	4000	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 27 records

SolventPlasticizerDeodorizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Construction and building materials; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; New Zealand; Toys and children's products	International Journal of Environmental Research and Public Health	Published Articles
detected; Toys and children's products	Springer	Published Articles
detected; Toys and children's products	Environmental Monitoring and Assessment	Published Articles
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
nondetect; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
banned; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Other direct contact consumer goods; Toys and children's products	Reproductive Toxicology	Published Articles
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
air; detected; emissions; Europe; Road vehicles	Danish Environmental Protection Agency	Danish EPA
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
31.2458203223546	uM	AC50	-	-	NTP_ICE_endocrine
1050	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
27500	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
74000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
>100000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
128824.9552	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
190000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
263000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
316227.766	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
820000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
23.0625321834709	uM	ACC	-	-	NTP_ICE_endocrine
=66	mg/kg bw/day	ADI	-	Rat	INCHEM_WHO_ehc_ehc_ehc189
1000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
AB8.7	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
AB8.7	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
AB8.7	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
AB8.7	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABdevelopmental, female, male	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental, female, male	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental, female, male	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental, female, male	listing type	California Proposition 65 listing	-	-	California Proposition 65
42.5	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
79.3	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=0.13	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
=4.17	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
-	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
56.42	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
4090	nM	EC50	-	-	NTP_ICE_endocrine
2286E5R2KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
2286E5R2KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
2286E5R2KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
2286E5R2KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.028	fraction	Fu	-	Human	NTP_ICE_adme_parameters
4800	nM	IC20	-	-	NTP_ICE_endocrine
<10000	nM	IC20	-	-	NTP_ICE_endocrine
500	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
2.868	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
4.25	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=6300	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7499	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=8000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=0.031	mg/kg bw/day	LEL	oral	rodent	ToxValDB_EPA_TSCA_8e
=0.063	mg/kg bw/day	LEL	oral	rodent	ToxValDB_EPA_TSCA_8e
=0.125	mg/kg bw/day	LEL	oral	rodent	ToxValDB_EPA_TSCA_8e
=0.25	mg/kg bw/day	LEL	oral	rodent	ToxValDB_EPA_TSCA_8e
100	nM	LEL	-	-	NTP_ICE_endocrine
=250	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=500	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=630	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=630	mg/kg bw/day	LEL	oral	rat (wistar; Wistar (Std:Wistar-KY))	ToxRefDB_ToxRefDB_v3_pod.csv

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Dibutyl phthalate	201-557-4	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Dibutyl phthalate	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. additional information becoming available on the adverse health effects of DBP; b. DBP being used in children’s toys and childcare articles at a concentration >0.5 %; c. additional sources of public exposure to DBP other than toys, childcare articles and cosmetics being identified; and d. additional information or events that change the assumptions for estimating the cumulative risk in this assessment. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIBUTYL PHTHALATE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 10 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,2-Benzenedicarboxylic acid, dibutyl ester?

1,2-Benzenedicarboxylic acid, dibutyl ester (CAS 84-74-2) is classified under EU CLP Annex VI as Repr. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H360Df; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,2-Benzenedicarboxylic acid, dibutyl ester?

1,2-Benzenedicarboxylic acid, dibutyl ester has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 1,2-Benzenedicarboxylic acid, dibutyl ester?

1,2-Benzenedicarboxylic acid, dibutyl ester appears on 33 regulatory/inventory lists including artificial_sweat; detected; emissions; Europe; Toys and children's products, Construction and building materials; detected; Europe, detected; Europe; Other indirect contact consumer goods, and 30 more. Source: EPA CPDat.

Is 1,2-Benzenedicarboxylic acid, dibutyl ester on the California Proposition 65 list?

Yes, 1,2-Benzenedicarboxylic acid, dibutyl ester is listed under California Proposition 65 for developmental, female, male. Source: California OEHHA Proposition 65.

Is 1,2-Benzenedicarboxylic acid, dibutyl ester a Substance of Very High Concern (SVHC)?

Yes, 1,2-Benzenedicarboxylic acid, dibutyl ester is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.

What are the occupational exposure limits for 1,2-Benzenedicarboxylic acid, dibutyl ester?

Occupational exposure limits for 1,2-Benzenedicarboxylic acid, dibutyl ester are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,2-Benzenedicarboxylic acid, dibutyl ester used in cosmetics?

Yes, 1,2-Benzenedicarboxylic acid, dibutyl ester is also indexed as a cosmetic ingredient under the name Dibutyl Phthalate (DBP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,2-Benzenedicarboxylic acid, dibutyl ester come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,2-Benzenedicarboxylic acid, dibutyl ester have different safety status in cosmetics vs industrial chemicals?

1,2-Benzenedicarboxylic acid, dibutyl ester is prohibited in EU cosmetics but has active industrial GHS classifications (H360Df, H400).

Is 1,2-Benzenedicarboxylic acid, dibutyl ester used outside industrial chemicals?

1,2-Benzenedicarboxylic acid, dibutyl ester also appears in cosmetics, pharmaceutical, food safety, cannabis databases.