What is the GHS hazard classification for Anthraquinone?
Anthraquinone (CAS 84-65-1) is classified under EU CLP Annex VI as Carc. 1B with signal word Danger. Hazard statements: H350. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
IARC Group 2B
Prop 65
REACH Registered
Cosmetic Ingredient
Anthraquinone
Also known as: 9,10-Anthraquinone, Anthracene, 9,10-dihydro-9,10-dioxo-, Anthrapel, Bis-alkylamino anthraquinone, Caswell No. 052A (+6 more)
CAS 84-65-1
Anthraquinone (CAS 84-65-1) is a chemical substance with GHS signal word Danger; key hazard signal: H350. Key regulatory status: California Proposition 65, REACH registered, 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC.
Cross-Vertical Regulatory Divergence
Anthraquinone is classified GHS Danger (H350) in the chemicals database but is restricted in EU cosmetics at max II/1603.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
41
SOURCE
chemical inventory jurisdictions
Regulatory lists
26
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Anthraquinone
CAS Number
84-65-1
DTXSID
DTXSID3020095
Molecular Formula
C14H8O2
InChI Key
RZVHIXYEVGDQDX-UHFFFAOYSA-N
Monoisotopic Mass
208.052429
Synonyms
9,10-AnthraquinoneAnthracene, 9,10-dihydro-9,10-dioxo-AnthrapelBis-alkylamino anthraquinoneCaswell No. 052AEINECS 201-549-0EPA Pesticide Chemical Code 1227019,10-AnthrachinonUNII-030MS0JBDO9,10-quinoneAz-Q
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2011 | 101 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B | H350 | GHS08 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | May cause mechanical irritation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DyeSurface modifierIntermediatePigment
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| Europe; Other direct contact consumer goods; residue | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| banned; Europe; Personal care | European Commission | CosIng |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 41 of 41 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =0.052 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =2.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 030MS0JBDO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 030MS0JBDO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 030MS0JBDO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 030MS0JBDO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >1.3 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~10 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1.44 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~2 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <160 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~5.2 | mg/m3 | NOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1.7 | mg/m3 | NOEL | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =1.7 | mg/m3 | NOEL | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| <=150 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <200 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 469 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 833 | ppm | POLY-3 lowest dose | Dosed feed | Mouse | NTP_ICE_cancer |
| 938 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 1875 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 3750 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| =0.002 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =0.01 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =0.002 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.002 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.011 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.011 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.0323 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.0323 | mg/kg bw/day | TDI | - | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.07 | mg/L | TDI | oral | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| =0.07 | mg/L | TDI | oral | - | INCHEM_WHO_iarc_iarcmono_v101iarc |
| 3750 | ppm | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
| 7500 | ppm | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
Showing 41 of 41 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Anthraquinone | 201-549-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
II/1603
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ANTHRAQUINONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What is the NOAEL for Anthraquinone?
Anthraquinone has 41 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
What regulatory lists include Anthraquinone?
Anthraquinone appears on 10 regulatory/inventory lists including banned; Europe; Personal care, Indirect additives food contact (10/2018), detected; ground_water; MN Chemical Screening, and 7 more. Source: EPA CPDat.
Is Anthraquinone a carcinogen according to IARC?
Anthraquinone is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2011). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Anthraquinone on the California Proposition 65 list?
Yes, Anthraquinone is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Anthraquinone used in cosmetics?
Yes, Anthraquinone is also indexed as a cosmetic ingredient under the name ANTHRAQUINONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Anthraquinone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Anthraquinone have different safety status in cosmetics vs industrial chemicals?
Anthraquinone is classified GHS Danger (H350) in the chemicals database but is restricted in EU cosmetics at max II/1603.
Is Anthraquinone used outside industrial chemicals?
Anthraquinone also appears in cosmetics, pharmaceutical databases.