NOAEL Data REACH Registered Cosmetic Ingredient

1,5-Dihydroxynaphthalene

Also known as: Naphthalene-1,5-diol, 4-06-00-06554, BRN 2044951, 1,5-Dihydroxynapthalene, EINECS 201-487-4 (+1 more)

CAS 83-56-7

1,5-Dihydroxynaphthalene (CAS 83-56-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 1,5-Naphthalenediol →

SOURCE NOAEL studies
NOAEL studies
49
SOURCE Chemical inventory jurisdictions
Regulatory lists
2
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
1,5-Dihydroxynaphthalene
CAS Number
83-56-7
DTXSID
DTXSID2052574
Molecular Formula
C10H8O2
InChI Key
BOKGTLAJQHTOKE-UHFFFAOYSA-N
Monoisotopic Mass
160.052429
Synonyms
Naphthalene-1,5-diol4-06-00-06554BRN 20449511,5-DihydroxynapthaleneEINECS 201-487-4UNII-P25HC23VH6

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is mildly irritating to the eyes.
Routes of ExposureThe substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 49 of 49 studies
ValueUnitEndpointRouteSpeciesSource
360mg/kg bw/day--humanRegulatory source
P25HC23VH6UNIIFDA UNII substance identifier--openFDA substances
P25HC23VH6UNIIFDA UNII substance identifier--openFDA substances
P25HC23VH6UNIIFDA UNII substance identifier--openFDA substances
P25HC23VH6UNIIFDA UNII substance identifier--openFDA substances
50mg/kg bw/dayLOAELoralratCOSMOS DB
=0.02mg/kg bw/dNOAELoralratSCCS Opinion
=0.02mg/kg bw/dNOAELoralratSCCS Opinion
=0.02mg/kg bw/dNOAELoralratSCCS Opinion
=0.02mg/kg bw/dNOAELoralratSCCS Opinion
=50mg/kg bw/dayNOAELoralRatECHA
=50mg/kg/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAELoralratSCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dNOAELoralratSCCS Opinion
=50mg/kg/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAELoralratSCCS Opinion
=50mg/kg/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAELoralratSCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dNOAELoralratSCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dNOAELoralratSCCS Opinion
=50mg/kg/dayNOAEL--SCCS Opinion
=50mg/kg bw/dayNOAELoralratSCCS Opinion
=50mg/kg bw/dayNOAEL--SCCS Opinion
=50mg/kg bw/dNOAELoralratSCCS Opinion
=360mg/kg bw/dayNOAEL-ratSCCS Opinion
=360mg/kg bw/dayNOAEL-humanSCCS Opinion
=360mg/kg bw/dayNOAEL-ratSCCS Opinion
=360mg/kg bw/dayNOAEL-ratSCCS Opinion
=360mg/kg bw/dayNOAEL-humanSCCS Opinion
=360mg/kg bw/dayNOAEL-humanSCCS Opinion
=360mg/kg bw/dayNOAEL-ratSCCS Opinion
=360mg/kg bw/dayNOAEL-humanSCCS Opinion
=0.02mg/kg bw/ddermal absorptionoralratRegulatory source
=50mg/kg bw/ddermal absorptionoralratRegulatory source
=50mg/kg bw/ddermal absorptionoralratRegulatory source
360mg/kg bw/daydevelopmental toxicity-ratRegulatory source
360mg/kg bw/daydevelopmental toxicity-ratRegulatory source
50mg/kg/daygenotoxicity--Regulatory source
50mg/kg/daygenotoxicity--Regulatory source
50mg/kg bw/daygenotoxicity--Regulatory source
50mg/kg bw/daygenotoxicity--Regulatory source
50mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
50mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
360mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
360mg/kg bw/dayrepeated dose toxicityoralratRegulatory source
360mg/kg bw/dayrepeated dose toxicityoralratRegulatory source

Showing 49 of 49 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredNaphthalene-1,5-diol201-487-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1412/1021 September 2010safe1.0%sensitisation potential not excluded
SCCP/1058/0721 March 2007safe1.0%sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.0%
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL204658
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,5-Dihydroxynaphthalene?

1,5-Dihydroxynaphthalene has 49 NOAEL studies in the database. The lowest reported value is 360 mg/kg bw/day in human. Source: Regulatory source.

What regulatory lists include 1,5-Dihydroxynaphthalene?

1,5-Dihydroxynaphthalene appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 1,5-Dihydroxynaphthalene used in cosmetics?

Yes, 1,5-Dihydroxynaphthalene is also indexed as a cosmetic ingredient under the name 1,5-Naphthalenediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,5-Dihydroxynaphthalene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,5-Dihydroxynaphthalene have different safety status in cosmetics vs industrial chemicals?

1,5-Dihydroxynaphthalene is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H319, H411).

Is 1,5-Dihydroxynaphthalene used outside industrial chemicals?

1,5-Dihydroxynaphthalene also appears in cosmetics, pharmaceutical databases.