What is the NOAEL for Deoxycholic acid?
Deoxycholic acid has 11 NOAEL studies in the database. The lowest reported value is 005990WHZZ UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Deoxycholic acid
Also known as: 4-10-00-01608, BRN 3219882, 5beta-Cholan-24-oic acid, 3alpha,12alpha-dihydroxy-, Cholan-24-oic, 3,12-dihydroxy-(3alpha,5beta,12alpha)-, Choleic acid (+15 more)
CAS 83-44-3
Deoxycholic acid (CAS 83-44-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Deoxycholic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
Deoxycholic acid
CAS Number
83-44-3
DTXSID
DTXSID0042662
Molecular Formula
C24H40O4
InChI Key
KXGVEGMKQFWNSR-LLQZFEROSA-N
Monoisotopic Mass
392.29266
Synonyms
4-10-00-01608BRN 32198825beta-Cholan-24-oic acid, 3alpha,12alpha-dihydroxy-Cholan-24-oic, 3,12-dihydroxy-(3alpha,5beta,12alpha)-Choleic acidDeoxy cholic acid5-beta-Deoxycholic acid3alpha,12alpha-Dihydroxy-5beta-cholanic acid3,12-Dihydroxycholanic acidDihydroxycholanoic acid3alpha,12alpha-Dihydroxy-5beta-cholan-24-oic acid3,12-Dihydroxycholan-24-oic acid, (3alpha,5beta,12alpha)-
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
HumectantSoftener and conditionerEmulsifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 005990WHZZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 005990WHZZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 005990WHZZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 005990WHZZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=5 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | unspecified | rat (Sprague-Dawley; male/female) | FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z |
| =50 | mg/kg bw/day | NOAEL | unspecified | rat (Sprague-Dawley; male/female) | FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z |
| =50 | mg/kg bw/day | NOAEL | unspecified | rat (Sprague-Dawley; male/female) | FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z |
| =50 | mg/kg bw/day | NOAEL | unspecified | rat (Sprague-Dawley; male/female) | FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-α,12-α-dihydroxy-5-β-cholan-24-oic acid | 201-478-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
DEOXYCHOLIC ACID
ChEMBL Phase
4
Adverse Events
26
Bioactivity
12
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-1.25 mg/kg bw mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Deoxycholic acid?
Deoxycholic acid appears on 3 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Canada; pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Deoxycholic acid used in cosmetics?
Yes, Deoxycholic acid is also indexed as a cosmetic ingredient under the name Deoxycholic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Deoxycholic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Deoxycholic acid have different safety status in cosmetics vs industrial chemicals?
Deoxycholic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H335).
Is Deoxycholic acid used outside industrial chemicals?
Deoxycholic acid also appears in cosmetics, pharmaceutical, food safety databases.