Also known as: 1,3-Benzenediamine, 2-methyl-, 3-13-00-00291, BRN 2079476, NSC 147490, o-Toluene diamine (+12 more)
CAS 823-40-5
2,6-Toluenediamine (CAS 823-40-5) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H312; H302; H317; H411. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
2,6-Toluenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H341, H312, H302, H317, H411).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2 | H341; H312; H302; H317; H411 | GHS08; GHS07; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| H838Q10551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H838Q10551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H838Q10551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H838Q10551 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =3000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =62 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =60 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| =250 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =0.03 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.06 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 12 of 12 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methyl-m-phenylenediamine | 212-513-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2,6-Toluenediamine (CAS 823-40-5) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2 with signal word Warning. Hazard statements: H341; H312; H302; H317; H411. Source: EU CLP Annex VI (ECHA).
2,6-Toluenediamine has 12 NOAEL studies in the database. The lowest reported value is H838Q10551 UNII. Source: openFDA substances.
2,6-Toluenediamine appears on 2 regulatory/inventory lists including detected; Europe; Toys and children's products, banned; Europe; Personal care. Source: EPA CPDat.
Yes, 2,6-Toluenediamine is also indexed as a cosmetic ingredient under the name Toluene-2,6-Diamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2,6-Toluenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H341, H312, H302, H317, H411).
2,6-Toluenediamine also appears in cosmetics, pharmaceutical databases.