Also known as: 2-propenoic acid, 2-hydroxyethyl ester, Acrylic acid 2-hydroxyethyl ester, BRN 0969853, EINECS 212-454-9, Ethylene glycol, acrylate (+4 more)
CAS 818-61-1
2-Hydroxyethyl acrylate (CAS 818-61-1) is a chemical substance with GHS signal word Danger; key hazard signal: H311; H314; H317; H400. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
2-Hydroxyethyl acrylate is classified GHS Danger (H311, H314, H317, H400) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 3 *; Skin Corr. 1B; Skin Sens. 1; Aquatic Acute 1 | H311; H314; H317; H400 | GHS06; GHS05; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Fatal in contact with skin or if inhaled Harmful if swallowed Causes skin irritation Causes serious eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways Very toxic to aquatic life |
| Short-term Effects | The substance is severely irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19.49 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.13 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.4 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.53 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 24.4 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =2.4 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 92.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 100 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 88.9 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 93.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 90.75 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 97 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 32.27 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 1.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 92.92 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 25GT92NY0C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25GT92NY0C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25GT92NY0C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25GT92NY0C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 207.17 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 54.85 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =85484.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 28 of 28 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-hydroxyethyl acrylate | 212-454-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Hydroxyethyl acrylate (CAS 818-61-1) is classified under EU CLP Annex VI as Acute Tox. 3 *; Skin Corr. 1B; Skin Sens. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H311; H314; H317; H400. Source: EU CLP Annex VI (ECHA).
2-Hydroxyethyl acrylate has 28 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
2-Hydroxyethyl acrylate appears on 2 regulatory/inventory lists including Cons electronics mech appliances and machinery; detected; Europe, Indirect additives food contact (10/2018). Source: EPA CPDat.
Yes, 2-Hydroxyethyl acrylate is also indexed as a cosmetic ingredient under the name 2-Hydroxyethyl Acrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Hydroxyethyl acrylate is classified GHS Danger (H311, H314, H317, H400) in the chemicals database but is allowed in EU cosmetics.
2-Hydroxyethyl acrylate also appears in cosmetics, pharmaceutical databases.