Also known as: 1-(4-(1,1-Dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)ethanone, 2-Acetyl-5-tert-butyl-4,6-dinitroxylene, 4-07-00-00808, Acetophenone, 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitro-, BRN 2062638 (+7 more)
CAS 81-14-1
Musk ketone (CAS 81-14-1) is a chemical substance with GHS signal word Warning; key hazard signal: H351; H400; H410. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Musk ketone is classified GHS CMR hazard (H351, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 1.4% fine fragrance; 0.56% eau de toilette; 0.042% other cosmetic products.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Aquatic Acute 1; Aquatic Chronic 1 | H351; H400; H410 | GHS08; GHS09 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.247 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 483V3E1L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 483V3E1L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 483V3E1L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 483V3E1L6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1986 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >10000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| 10 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 20 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 45 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =45 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =75 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone | 201-328-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Musk ketone (CAS 81-14-1) is classified under EU CLP Annex VI as Carc. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H351; H400; H410. Source: EU CLP Annex VI (ECHA).
Musk ketone has 18 NOAEL studies in the database. The lowest reported value is 0.247 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Musk ketone appears on 6 regulatory/inventory lists including Europe; Personal care; restricted, children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 3 more. Source: EPA CPDat.
Yes, Musk ketone is also indexed as a cosmetic ingredient under the name Musk Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Musk ketone is classified GHS CMR hazard (H351, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 1.4% fine fragrance; 0.56% eau de toilette; 0.042% other cosmetic products.
Musk ketone also appears in cosmetics, pharmaceutical, food safety databases.