What is the NOAEL for Saccharin?
Saccharin has 44 NOAEL studies in the database. The lowest reported value is 3.8 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
IARC Group 3
Prop 65
REACH Registered
Cosmetic Ingredient
Saccharin
Also known as: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one, Benzosulfimide, O-, EINECS 201-321-0, RCRA waste number U202 (+15 more)
CAS 81-07-2
Saccharin (CAS 81-07-2) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: California Proposition 65, REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, EPA TRI.
SOURCE
noael studies public
NOAEL studies
44
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Saccharin
CAS Number
81-07-2
DTXSID
DTXSID5021251
Molecular Formula
C7H5NO3S
InChI Key
CVHZOJJKTDOEJC-UHFFFAOYSA-N
Monoisotopic Mass
182.999014
Synonyms
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-oneBenzosulfimide, O-EINECS 201-321-0RCRA waste number U202SaccharinaSulfobenzimide, O-NSC 5731UNII-FST467XS7D1, 2-Benzisothiazol-3(2H)-one, 1,1-dioxide1, 2-Benzisothiazolin-3-one 1,1-dioxide1, 2-Dihydro-2-ketobenzisosulfonazole
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | Sup 7, 73 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 44 of 44 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.8 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =3.8 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| >1282.26 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| <1000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| LCcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| LCcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| LCcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| LCcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 1.917 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =131.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2.4 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 48.7 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -2.4 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.2 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 24 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| FST467XS7D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FST467XS7D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FST467XS7D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FST467XS7D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.2258 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 1.1 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| >8440 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <9710 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =14200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =0.0001 | mg/org | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =50 | mg/L | LOEL | environmental | Rat | ToxValDB_ECOTOX |
| =200 | mmol/kg | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1000 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =286 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =353 | mg/kg bw/day | NOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| =714 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOAEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| =2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.0001 | mg/org | NOEL | injection | Rat | ToxValDB_ECOTOX |
| =1 | mM | NOEL | environmental | Rat | ToxValDB_ECOTOX |
| =5 | mg/L | NOEL | environmental | Rat | ToxValDB_ECOTOX |
| =100 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| =800 | mg/L | NOEL | environmental | Rat | ToxValDB_ECOTOX |
Showing 44 of 44 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,2-benzisothiazol-3(2H)-one 1,1-dioxide | 201-321-0 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Saccharin (manufacturers only) | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SACCHARIN
ChEMBL Phase
3
Adverse Events
0
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Saccharin?
Saccharin appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, animal_products, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is Saccharin a carcinogen according to IARC?
Saccharin is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Saccharin on the California Proposition 65 list?
Yes, Saccharin is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Saccharin used in cosmetics?
Yes, Saccharin is also indexed as a cosmetic ingredient under the name Saccharin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Saccharin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Saccharin used outside industrial chemicals?
Saccharin also appears in cosmetics, pharmaceutical, cannabis databases.