What is the NOAEL for Simethicone?
Simethicone has 1 NOAEL study in the database. The lowest reported value is 1.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Cosmetic Ingredient
Simethicone
Also known as: simeticone, EC No.: 617-098-1, Antifoam A, Dimethyl polysiloxane, Mylicon (+15 more)
CAS 8050-81-5
Simethicone (CAS 8050-81-5) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
1
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Simethicone
CAS Number
8050-81-5
DTXSID
DTXSID00904918
Synonyms
simeticoneEC No.: 617-098-1Antifoam ADimethyl polysiloxaneMyliconSilfoam SE 2Aligest PlusBarcroft SIM-DC 100DC Antifoam ADow Antifoam ADow Corning Antifoam AEspumisan
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
25 records
DefoamerSoftener and conditionerAnti-adhesive/cohesiveFlow promoter
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 1 of 1 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=1.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
Showing 1 of 1 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Frequently Asked Questions
What regulatory lists include Simethicone?
Simethicone appears on 6 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, and 3 more. Source: EPA CPDat.
Is Simethicone used in cosmetics?
Yes, Simethicone is also indexed as a cosmetic ingredient under the name Simethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Simethicone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Simethicone used outside industrial chemicals?
Simethicone also appears in cosmetics databases.