What is the NOAEL for Peppermint oil?
Peppermint oil has 18 NOAEL studies in the database. The lowest reported value is 33.5252100339392 uM. Source: NTP_ICE_endocrine.
NOAEL Data
Cosmetic Ingredient
Peppermint oil
Also known as: Mentha Piperita (Peppermint) Leaf Water, EC No.: 616-900-7, English black mint oil, FEMA No. 2848, Peppermint oleoresin/extract (Mentha piperita L.) (+3 more)
CAS 8006-90-4
Peppermint oil (CAS 8006-90-4) is a chemical substance. Key regulatory status: 26 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
26
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Peppermint oil
CAS Number
8006-90-4
DTXSID
DTXSID6021113
Synonyms
Mentha Piperita (Peppermint) Leaf WaterEC No.: 616-900-7English black mint oilFEMA No. 2848Peppermint oleoresin/extract (Mentha piperita L.)Pfefferminz oelUNII-AV092KU4JHMentharil
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
FragranceDeodorizerHumectantSoftener and conditionerFlavouring and nutrientBiocideDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
26 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| IFRA Transparency | IFRA | IFRA |
| IFRA Transparency | IFRA | IFRA |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Europe; Personal care - body oil | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 40 | mg/kg/d | - | - | rat | UnifiedCodex:CIR:beta.noael_studies |
| 33.5252100339392 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 67.2663767739755 | uM | ACC | - | - | NTP_ICE_endocrine |
| AV092KU4JH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AV092KU4JH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AV092KU4JH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AV092KU4JH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00851 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =40 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =40 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =40 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| =40 | mg/kg/d | NOAEL | - | rat | CIR_vision_codex |
| 75 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 125 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 747 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 18 of 18 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Multiple fragrance allergen components require disclosure >30 ppm in leave-on products
Category
essential oil
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
285
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Peppermint oil?
Peppermint oil appears on 12 regulatory/inventory lists including Europe; Personal care, Europe; Personal care - oral and dental care - teeth whitener, active_ingredient; Pesticides, and 9 more. Source: EPA CPDat.
Is Peppermint oil used in cosmetics?
Yes, Peppermint oil is also indexed as a cosmetic ingredient under the name Mentha Piperita Oil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Peppermint oil come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Peppermint oil used outside industrial chemicals?
Peppermint oil also appears in cosmetics, pharmaceutical, food safety, cannabis databases.