Danger GHS08GHS07GHS05GHS09 NOAEL Data SVHC Prop 65 REACH Registered Cosmetic Ingredient

Bisphenol A

Also known as: BPA, 4,4’-Propane-2,2-diyldiphenol, Phenol, 4,4'-(1-methylethylidene)bis-, 4-06-00-06717, 2,2-Bis(hydroxyphenyl)propane (+15 more)

CAS 80-05-7

Bisphenol A (CAS 80-05-7) is a chemical substance with GHS signal word Danger; key hazard signal: H360F; H335; H318; H317; H400; H410. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, EPA TRI.

View cosmetic safety profile for 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) →

Cross-Vertical Regulatory Divergence

Bisphenol A is prohibited in EU cosmetics but has active industrial GHS classifications (H360F, H335, H318, H317, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Bisphenol A

CAS Number

80-05-7

DTXSID

DTXSID7020182

Molecular Formula

C15H16O2

InChI Key

IISBACLAFKSPIT-UHFFFAOYSA-N

Monoisotopic Mass

228.11503

Synonyms

BPA4,4’-Propane-2,2-diyldiphenolPhenol, 4,4'-(1-methylethylidene)bis-4-06-00-067172,2-Bis(hydroxyphenyl)propaneBRN 1107700beta-Di-p-hydroxyphenylpropaneEINECS 201-245-8NCI-C50635Phenol, 4,4'-dimethylmethylenedi-Phenol, (1-methylethylidene)bis-Propane, 2,2-bis(p-hydroxyphenyl)-

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA (EU) 1 records

Substance	Reason	Included
4,4'-isopropylidenediphenol	Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health)	12-Jan-2017

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 2 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	female	No	No	-
-	developmental	No	Yes	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1	H360F; H335; H318; H317; H400; H410	GHS08; GHS07; GHS05; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Causes serious eye irritation May cause an allergic skin reaction Suspected of damaging fertility or the unborn child May cause respiratory irritation Toxic to aquatic life
Short-term Effects	The substance is severely irritating to the eyes. The substance is mildly irritating to the respiratory tract.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization and photosensitization. The substance may have effects on the upper respiratory tract. Ingestion may cause effects on the liver and kidneys. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 36 records

BinderHardenerCatalystMonomersAntioxidantNo specific technical functionFlame retardant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records

List	Keyword	Source
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
detected; Toys and children's products	Springer	Published Articles
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
Cons electronics mech appliances and machinery; Europe	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
detected; wastewater	USGS	United States Geological Survey (USGS)
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; MN Chemical Screening; surface_water	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	National Parks Service	State of Minnesota
detected; MN Chemical Screening; surface_water	National Parks Service	State of Minnesota
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; MN Chemical Screening; wastewater	Minnesota Pollution Control Agency	State of Minnesota
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
detected; ground_water; MN Chemical Screening	Minnesota Pollution Control Agency	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA & USGS	State of Minnesota
detected; MN Chemical Screening; surface_water	Minnesota Pollution Control Agency	State of Minnesota
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
children	Vermont Department of Health	State of Vermont
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
banned; Europe	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
children; Europe	Danish Environmental Protection Agency	Danish EPA
children; Europe	Danish Environmental Protection Agency	Danish EPA
Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
0.669617515126504	uM	AC50	-	-	NTP_ICE_endocrine
16.8348356403529	uM	AC50	-	-	NTP_ICE_endocrine
0.1585	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
80	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
158.489	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
318	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
746	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
920	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
1800	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
2340	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
2500	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
2800	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
3200	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
4200	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
4300	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
5000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
5250	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
5700	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
7000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
7900	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
11800	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
19600	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
39000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
55380	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
62700	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
75000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
110000	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
1000001453	nM	AC50/EC50/IC50	-	-	NTP_ICE_endocrine
0.228354371372336	uM	ACC	-	-	NTP_ICE_endocrine
17.0951719331564	uM	ACC	-	-	NTP_ICE_endocrine
=0.609	mg/kg bw/day	BMDL (10)	oral	Mouse	ToxValDB_EFSA
=8.96	mg/kg bw/day	BMDL (10)	oral	Mouse	ToxValDB_EFSA
SQEdermal=3	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
SQEdermal=3	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
SQEdermal=3	ug/day	California Proposition 65 MADL	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
ABdevelopmental	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEfemale	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEfemale	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEfemale	listing type	California Proposition 65 listing	-	-	California Proposition 65
2.326	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
19.9	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=2	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
533	nM	EC50	-	-	NTP_ICE_endocrine
MLT3645I99	UNII	FDA UNII substance identifier	-	-	openFDA substances
MLT3645I99	UNII	FDA UNII substance identifier	-	-	openFDA substances
MLT3645I99	UNII	FDA UNII substance identifier	-	-	openFDA substances
MLT3645I99	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0385	fraction	Fu	-	Human	NTP_ICE_adme_parameters

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4,4'-isopropylidenediphenol	201-245-8	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
4,4'-Isopropylidenediphenol (Bisphenol A)	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1620/20	30-31 March 2021	safe with restrictions	Max ~0.8 mg/kg textile for systemic protection	BPA present in clothing; MoS 1406 (adults) and 931 (toddlers) - no risk from clothing alone; only one migration study available; limit value to be confirmed; no risk for systemic health effects from clothing use

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BISPHENOL A

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0.2 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Bisphenol A?

Bisphenol A (CAS 80-05-7) is classified under EU CLP Annex VI as Repr. 1B; STOT SE 3; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H360F; H335; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Bisphenol A?

Bisphenol A has 100 NOAEL studies in the database. The lowest reported value is 0.0385 fraction in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Bisphenol A?

Bisphenol A appears on 33 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, detected; Toys and children's products, active_ingredient; Pesticides, and 30 more. Source: EPA CPDat.

Is Bisphenol A on the California Proposition 65 list?

Yes, Bisphenol A is listed under California Proposition 65 for female. Source: California OEHHA Proposition 65.

Is Bisphenol A a Substance of Very High Concern (SVHC)?

Yes, Bisphenol A is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.

Is Bisphenol A used in cosmetics?

Yes, Bisphenol A is also indexed as a cosmetic ingredient under the name 4,4'-Isopropylidenediphenol (Bisphenol A / BPA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Bisphenol A come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Bisphenol A have different safety status in cosmetics vs industrial chemicals?

Bisphenol A is prohibited in EU cosmetics but has active industrial GHS classifications (H360F, H335, H318, H317, H400, H410).

Is Bisphenol A used outside industrial chemicals?

Bisphenol A also appears in cosmetics, pharmaceutical, food safety, cannabis databases.