What is the NOAEL for Propanoic acid, 2-mercapto-?
Propanoic acid, 2-mercapto- has 12 NOAEL studies in the database. The lowest reported value is 0.36 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propanoic acid, 2-mercapto-
CAS 79-42-5
Propanoic acid, 2-mercapto- (CAS 79-42-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Propanoic acid, 2-mercapto- is classified GHS Danger (H301, H311, H314, H330) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
Propanoic acid, 2-mercapto-
CAS Number
79-42-5
DTXSID
DTXSID80861636
Molecular Formula
C3H6O2S
InChI Key
PMNLUUOXGOOLSP-UHFFFAOYSA-N
Monoisotopic Mass
106.008851
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
AntioxidantDeodorizerReducing agentDepilatoryHair waving or straighteningFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.738 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.36 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.49 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| O5U6967KGF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5U6967KGF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5U6967KGF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O5U6967KGF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9.756 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1701 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 871.5 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 425.1 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-mercaptopropionic acid | 201-206-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL2158192
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Propanoic acid, 2-mercapto-?
Propanoic acid, 2-mercapto- appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Propanoic acid, 2-mercapto- used in cosmetics?
Yes, Propanoic acid, 2-mercapto- is also indexed as a cosmetic ingredient under the name Thiolactic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propanoic acid, 2-mercapto- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Propanoic acid, 2-mercapto- have different safety status in cosmetics vs industrial chemicals?
Propanoic acid, 2-mercapto- is classified GHS Danger (H301, H311, H314, H330) in the chemicals database but is restricted in EU cosmetics.
Is Propanoic acid, 2-mercapto- used outside industrial chemicals?
Propanoic acid, 2-mercapto- also appears in cosmetics, pharmaceutical databases.