What is the NOAEL for Methacrylamide?
Methacrylamide has 39 NOAEL studies in the database. The lowest reported value is 2.54 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methacrylamide
Also known as: 2-Propenamide, 2-methyl-, 2-Methylprop-2-enamide, 2-propenamida, 2-metil, BRN 0605397, Caswell No. 549 (+8 more)
CAS 79-39-0
Methacrylamide (CAS 79-39-0) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Methacrylamide is classified GHS CMR hazard (H302, H319, H335, H371, H373, H320, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
39
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Methacrylamide
CAS Number
79-39-0
DTXSID
DTXSID8029600
Molecular Formula
C4H7NO
InChI Key
FQPSGWSUVKBHSU-UHFFFAOYSA-N
Monoisotopic Mass
85.052764
Synonyms
2-Propenamide, 2-methyl-2-Methylprop-2-enamide2-propenamida, 2-metilBRN 0605397Caswell No. 549EINECS 201-202-3EPA Pesticide Chemical Code 052901MethacryamideMethylacrylic amideMhoromer BM801Amid kyseliny methakryloveUNII-K67NG89J77
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 39 of 39 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.54 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =7.89 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| K67NG89J77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K67NG89J77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K67NG89J77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K67NG89J77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =459 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1653 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1815 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1938 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =200 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =360 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| ~450 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| ~500 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~1300 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| =1315 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~1500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =6.8 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =3.2 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =10 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =12.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =12.8 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~20 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~33.6 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =49 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =62.5 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =69 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =71.3 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =90 | mg/kg bw/day | NOAEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =125 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~210 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | NOAEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
Showing 39 of 39 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methacrylamide | 201-202-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL158237
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Methacrylamide?
Methacrylamide appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Methacrylamide used in cosmetics?
Yes, Methacrylamide is also indexed as a cosmetic ingredient under the name Methacrylamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methacrylamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Methacrylamide have different safety status in cosmetics vs industrial chemicals?
Methacrylamide is classified GHS CMR hazard (H302, H319, H335, H371, H373, H320, H361) in the chemicals database but is allowed in EU cosmetics.
Is Methacrylamide used outside industrial chemicals?
Methacrylamide also appears in cosmetics, pharmaceutical databases.