Also known as: 4-02-00-00843, Acetic acid, dimethyl-, BRN 0635770, Caswell No. 503AA, Cenex RP b2 (+15 more)
CAS 79-31-2
2-Methylpropanoic acid (CAS 79-31-2) is a chemical substance with GHS signal word Warning; key hazard signal: H312; H302. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 * | H312; H302 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =184 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 8LL210O1U0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8LL210O1U0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8LL210O1U0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8LL210O1U0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =266 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =280 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2230 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2518 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =72070.7 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
Showing 26 of 26 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isobutyric acid | 201-195-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →2-Methylpropanoic acid (CAS 79-31-2) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H312; H302. Source: EU CLP Annex VI (ECHA).
2-Methylpropanoic acid has 26 NOAEL studies in the database. The lowest reported value is 184 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
2-Methylpropanoic acid appears on 6 regulatory/inventory lists including Europe, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Yes, 2-Methylpropanoic acid is also indexed as a cosmetic ingredient under the name Isobutyric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
2-Methylpropanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.