Also known as: EINECS 201-185-2, FEMA No. 2676, FEMA Number 2676, UNII-W684QT396F, AcOMe (+15 more)
CAS 79-20-9
Methyl acetate (CAS 79-20-9) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H336; H319. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Methyl acetate is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 | H225; H336; H319 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Causes eye irritation May cause drowsiness or dizziness |
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. The substance may cause effects on nervous system. Exposure far above the OEL could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the optic nerve. This may result in impaired vision. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 200 ppm (610 mg/m³) | 200 | 610 | N |
| NIOSH | TWA | 200 ppm (610 mg/m³) | 200 | 610 | N |
| NIOSH | STEL | 250 ppm (760 mg/m³) | 250 | 760 | N |
| ACGIH | TWA | 200 ppm [2012] | 200 | - | N |
| ACGIH | STEL | 250 ppm [2012] | 250 | - | N |
| CAL/OSHA | TWA | 200 ppm (610 mg/m³) | 200 | 610 | N |
| CAL/OSHA | STEL | 250 ppm (760 mg/m³) | 250 | 760 | N |
| NIOSH | IDLH | 3100 ppm | 3100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =620 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =300 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 39.5 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| W684QT396F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W684QT396F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W684QT396F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W684QT396F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.16 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| =93924.8 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 10 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =500 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =500 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 29.2 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.1 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
Showing 20 of 20 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl acetate | 201-185-2 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Methyl acetate (CAS 79-20-9) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H336; H319. Source: EU CLP Annex VI (ECHA).
Methyl acetate has 20 NOAEL studies in the database. The lowest reported value is 39.5 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
Methyl acetate appears on 6 regulatory/inventory lists including Arts and crafts/Office supplies; Europe, detected; drinking_water; MN Chemical Screening, IFRA Transparency, and 3 more. Source: EPA CPDat.
Occupational exposure limits for Methyl acetate are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Methyl acetate is also indexed as a cosmetic ingredient under the name Methyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Methyl acetate is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
Methyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.